|ANR-FWF Project: NMR Investigation of MAGnetization-Induced Non-linear Effects|
Globally large efforts are dedicated to improve the sensitivity of NMR mainly via two complementary approaches:
However these developments entail the appearance of new phenomena related to the non-linear evolution of nuclear magnetization in liquid samples (See for instance for a review in this field).
In most cases they result from the intricate combination of:
These effects are actually met in a wide range of other physical systems (such as Bose-Einstein condensates, superfluid 3He, or quantum entangled spin systems).
The first aim of this project consists in significantly improving the understanding of these new physical phenomena and their consequences on the NMR observables: for instance deciphering the complex line shapes of nuclear spin-noise spectra acquired with cold probes, explaining the origin of multiple maser emissions, or controlling DDF-induced spin dynamics instabilities through multiple rf-pulses. Such studies will require means to increase and control both the magnetization and its cross-talk with the detection coil. To this end hyperpolarized noble gases or parahydrogen, areas of expertise of IRAMIS and LKB, will be employed whenever possible. Use of cold probes available at JKU as well as development of micro-coils will further lower the detection threshold of NMR, allowing us to induce and study novel effects.
The second major aim of the project is either to find new ways to circumvent the drawbacks resulting from these non-linear effects (such as unreliable suppression of the solvent signals), or to propose new approaches to turn them into advantages. For instance, as the coupling between the magnetization and the coil tremendously enhances the detection sensitivity of spin-noise, the latter is expected to be more sensitive than classical pulse-acquisition schemes for very small numbers of spins. Also, DDFs induced by large magnetization allow new approaches in MRI and localized NMR spectroscopy, thanks to intermolecular multiple-quantum coherences between target molecules and solvent or hyperpolarized species.
The consortium comprises four partners. Three belong to academic institutions and have the leadership in their respective research domains. Two laboratories of IRAMIS are involved, LSDRM for NMR and optical pumping and LICSEN for microfabication. The group of Pr. N. Müller at J. Kepler University in Linz (Austria) contributes with crucial experience in theory and practice of spin-noise phenomena on protons and provides the chemistry background required for the main-stream spectroscopic applications in high resolution NMR. The group of P.J. Nacher (Laboratory Kastler-Brosel, Ecole Normale Supérieure, Paris) specializes in optical pumping techniques and in low field NMR with full control of non-linear effects. The fourth Partner RS2D is a small company offering a-la-carte solutions in NMR spectroscopy and imaging; it will benefit from efficient transfers of knowledge and technologies and will provide hardware solutions to the academic partners for further enhancement of their capabilities to explore and exploit non-linear NMR. The Partners will take advantage of their complementary cultures, know-how and experimental apparatuses to treat various theoretical questions and to propose a variety of experimental applications, of different levels of risk and complexities. At the end of the project, the fundamental understanding of the phenomena arising from non-linear effects will provide a set of novel solutions for long-standing issues of NMR: new technologies to improve sensitivity and selectivity in NMR-spectroscopy and spatial resolution in MR-imaging based on scientifically sound extendable concepts of non-linear spin dynamics.
This project follows several previous works performed between only two partners out of the four. We can mention the ANR 2007 project DIPOL between LKB and LSDRM or the bi-national Amadeus project (2010-2011) between N. Müller and H. Desvaux.
The project has officially started for the French teams March 1st, and it will start May 1st in Austria. The kick-off meeting took place March 26th in Saclay.
In the framework of a bilateral collaboration project (Austria-France) and thanks to the WTZ Amadée Award 2013, N. Müller and H. Desvaux organize the 1
Several progresses have been performed and recently reported in the litterature.
Other progresses are on-going and will be reported shortly.
Maj : 26/10/2015 (2048)