PhD Student
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PhD Topic : Porous material-based devices for enhanced glycomics analysis
Glycomics consists to identify oligosaccharides present in a biological fluid as a source of biomarkers for the diagnosis of various pathologies (cancers, Alzheimer’s disease, etc.). However, the materials currently used in the protocols include time-consuming steps that are incompatible with high-throughput analysis.
In this context, LEDNA, a laboratory specialising in materials, recently developed a sol-gel process for manufacturing Hierarchical Porosity Monoliths (HPMs) in miniaturised devices. These materials provided a proof of concept showing their potential for the purification and extraction of oligosaccharides. LEDNA is now looking to improve the first stage, corresponding to enzymatic cleavage, which has become a limiting factor in the glycomics analysis process. The functionalization of porous materials, in particular HPMs, with enzyme would make it possible to prepare a simple sample in just a few hours with a single step.