| | | | | | | webmail : intra-extra| Accès VPN| Accès IST| Contact
5 sujets /NIMBE/LIONS

Dernière mise à jour :


 

Nano-object simulations in biological media

SL-DRF-24-0362

Research field : Biotechnologies,nanobiology
Location :

Service Nanosciences et Innovation pour les Materiaux, la Biomédecine et l’Energie (NIMBE)

Laboratoire Interdisciplinaire sur l’Organisation Nanométrique et Supramoléculaire (LIONS)

Saclay

Contact :

Yves BOULARD

Jean-Philippe RENAULT

Starting date : 01-09-2024

Contact :

Yves BOULARD
CEA - DRF/JOLIOT/I2BC/

+33 169083584

Thesis supervisor :

Jean-Philippe RENAULT
CEA - DRF/IRAMIS/NIMBE/LIONS

01 69 08 15 50

Personal web page : https://iramis.cea.fr/Phocea/Membres/Annuaire/index.php?uid=jrenault

Laboratory link : https://iramis.cea.fr/nimbe/lions/

Understanding the non-specific or specific interactions between biomolecules and nanomaterials is key to the development of safe nanomedicines and nanoparticles. Indeed, adsorption of biomolecules is the first process occurring after the introduction of biomaterials into the human body, which controls their biological response. In this thesis, we will simulate the interface between nanosystems and biomolecules on a scale of a hundred nanometers, using the new exascale computing resources available at the CEA from 2025 (Jules Verne machine installed at the CCRT).
Development of dense and fluidized granular beds in microfluidic channels for healthcare applications

SL-DRF-24-0399

Research field : Health and environment technologies, medical devices
Location :

Service Nanosciences et Innovation pour les Materiaux, la Biomédecine et l’Energie (NIMBE)

Laboratoire Interdisciplinaire sur l’Organisation Nanométrique et Supramoléculaire (LIONS)

Saclay

Contact :

Florent Malloggi

Starting date : 01-10-2024

Contact :

Florent Malloggi
CEA - DSM/IRAMIS/NIMBE/LIONS

+3316908 6328

Thesis supervisor :

Florent Malloggi
CEA - DSM/IRAMIS/NIMBE/LIONS

+3316908 6328

Personal web page : https://iramis.cea.fr/nimbe/Pisp/florent.malloggi/

Laboratory link : https://iramis.cea.fr/en/Pisp/lions/

The major public health problem of sepsis requires breakthrough technologies for ultra-fast diagnosis. Dense, fluidized granular beds are ideal systems for liquid-solid or gas-solid exchange processes. They are widely used in industry thanks to their high surface-to-volume ratio. Over the past decade, microfluidics and lab-on-a-chip have enabled numerous advances, particularly in biological sample preparation. We propose to develop a versatile microfluidic platform that will enable the creation of such dense, fluidized beds. We will first work on the incorporation of membranes into microchannels, drawing on the patented know-how developed in the laboratory. We will then study and characterize the granular beds, and finally test them for the detection of bacteria in biological samples. This work will be carried out in collaboration with our physicists (LEDNA) and biologist (LERI) partners at CEA Saclay.
Catalysis using sustainaBle hOllow nanoreacTors wiTh radiaL pErmanent polarization

SL-DRF-24-0284

Research field : Radiation-matter interactions
Location :

Service Nanosciences et Innovation pour les Materiaux, la Biomédecine et l’Energie (NIMBE)

Laboratoire Interdisciplinaire sur l’Organisation Nanométrique et Supramoléculaire (LIONS)

Saclay

Contact :

Pierre PICOT

Sophie LE CAER

Starting date : 01-10-2024

Contact :

Pierre PICOT
CEA - DRF/IRAMIS/NIMBE/LIONS/


Thesis supervisor :

Sophie LE CAER
CNRS - DRF/IRAMIS/NIMBE/LIONS

01 69 08 15 58

Personal web page : https://iramis.cea.fr/Phocea/Membres/Annuaire/index.php?uid=ppicot

Laboratory link : https://iramis.cea.fr/NIMBE/LIONS/

The combined demands of increasing energy production and the need to reduce fossil fuels to limit global warming have paved the way for an urgent need for clean energy harvesting technologies. One interesting solution is to use solar energy to produce fuels. Thus, low-cost materials such as semiconductors have been intensively studied for photocatalytic reactions. Among them, 1D nanostructures hold promise due to their interesting properties (high specific and accessible surfaces, confined environments, better charge separation). Imogolite, a natural hollow nanotube clay belongs to this category. Although it is not directly photoactive in the visible light range (high band gap), it exhibits a permanent wall polarization due to its intrinsic curvature. This property makes it a potentially useful co-photocatalyst for charge separation. Moreover, this nanotube belongs to a family sharing the same local structure with different curved morphologies (nanosphere and nanotile). In addition, several modifications of these materials are possible (wall doping with metals, coupling with metal nanoparticles, functionalization of the internal cavity) allowing tuning band gap. The proof of concept (i.e., photocatalytic nanoreactor) was only obtained for the nanotube form.

This phD project aims to study the whole family (nanotube, nanosphere, and nanotile, with various functionalizations) as nanoreactors for reduction reactions of protons and CO2 triggered under irradiation.
Raw earth soil, an age-old material with new emerging uses

SL-DRF-24-0360

Research field : Ultra-divided matter, Physical sciences for materials
Location :

Service Nanosciences et Innovation pour les Materiaux, la Biomédecine et l’Energie (NIMBE)

Laboratoire Interdisciplinaire sur l’Organisation Nanométrique et Supramoléculaire (LIONS)

Saclay

Contact :

Jean-Philippe RENAULT

Diane REBISCOUL

Starting date : 01-09-2024

Contact :

Jean-Philippe RENAULT
CEA - DRF/IRAMIS/NIMBE/LIONS

01 69 08 15 50

Thesis supervisor :

Diane REBISCOUL
CEA - DES/ICSM (DES)//L2ME

0033 4 66 33 93 30

Personal web page : https://iramis.cea.fr/Phocea/Membres/Annuaire/index.php?uid=jrenault

Laboratory link : https://iramis.cea.fr/nimbe/lions/

More : https://www.icsm.fr/index.php?pagendx=3898

Raw earth materials, which have found multiple uses for millennia, now offer considerable potential for helping to adapt to the changing climate, thanks to their natural ability to regulate heat and water, as well as their low-CO2 production and shaping. However, scientific advances are still needed to get a more precise understanding of these materials, up to the nanometric scale.

This thesis focuses on the link between the mechanical properties of raw earth soil materials and their nanostructure, emphasizing the roles of confined water, ions and organic substances. Two approaches, based on the expertise on nanoporous media developed at CEA, Saclay and Marcoule, will be followed: the analysis of old materials using spectroscopic and radiation scattering methods, and the development of a screening protocol to identify physicochemical parameters important for durability. This research, which ultimately aims to optimize the formulation of raw earth materials, will be carried out in collaboration with architects specialists in the field.
Multiscale metamaterials based on 3D-printed biosourced polymer composites

SL-DRF-24-0326

Research field : Ultra-divided matter, Physical sciences for materials
Location :

Service Nanosciences et Innovation pour les Materiaux, la Biomédecine et l’Energie (NIMBE)

Laboratoire Interdisciplinaire sur l’Organisation Nanométrique et Supramoléculaire (LIONS)

Saclay

Contact :

Valérie GEERTSEN

Starting date : 01-10-2024

Contact :

Valérie GEERTSEN
CEA - DRF/IRAMIS/NIMBE/LIONS

0643360545

Thesis supervisor :

Valérie GEERTSEN
CEA - DRF/IRAMIS/NIMBE/LIONS

0643360545

Personal web page : https://iramis.cea.fr/Pisp/valerie.geertsen/

Laboratory link : https://iramis.cea.fr/nimbe/lions/

Reducing the density of materials is one of the best ways to diminish our energy footprint. One solution is to replace massive materials by microlattices. Among these, random architecture structures inspired by bird bone structure offer the best advantages, with isotropic mechanical behavior and increased mechanical resistance, while meeting the challenges of the circular economy. These material-saving metamaterials are manufactured by 3D printing and can be compacted at the end of their life cycle. Among manufacturing technologies, UV polymerization of liquid organic resin or composite is the most promising. It produces mechanically resistant materials without generating manufacturing waste. It is also possible to include large quantities of bio-sourced fillers, reducing even further their environmental impact.

The PhD-thesis proposed here focuses on the development of polymeric nanocomposite microlattice structures from resin formulation to mechanical properties study (viscoelasticity, yield stress, fracture resistance) through printing and post-processing stages. From a more fundamental point of view, the aim is to study the link between the composition, shape and surface properties of the fillers on one hand, and the imprimability of the composite resine and the mechanical properties of the resulting metamaterial on the other hand. The thesis will focus on the study of cellulose-type fillers in nanoparticle, microparticle or fiber form. This multidisciplinary study bridges technology to science while producing data for a digital twin.

 

Retour en haut