Supramolecular architectures of biomolecules have been attracted much attention, because they hold great potential as a key component of materials for biomedical and bioelectronic applications. The construction of biomacromolecular assemblies with well-defined nanostructures has thus been a focal point of recent researches. We have been focused on a system containing hemoproteins, which function as an electron transfer mediator, catalyst, sensor, and gas storage. Previously, artificial hemoprotein assemblies via noncovalent heme−heme pocket interaction were constructed in our group.1 We then strive to expand this strategy to develop novel conjugates of the hemoprotein assemblies to combine with other biomolecules, nanoparticles, polymers.2 The supramolecular self-assembling systems of hemoproteins also allowed us to immobilize these assemblies on an electrode surface.3 We will present our recent work on the programmed hemoprotein assemblies as functional biomaterials and bioelectronics interfaces.
References and Footnotes
1) (a) K. Oohora, A. Onoda, T. Hayashi, Chem. Commun., 48, 11714 (2012). (c) K. Oohora, A. Onoda, H. Kitagishi, H. Yamaguchi, A. Harada, T. Hayashi, Chem. Sci., 2, 1033 (2011). Back Cover. (d) K. Oohora, S. Burazerovic, A. Onoda, Y. M. Wilson, T. R. Ward, T. Hayashi, Angew. Chem. Int. Ed., 51, 3818 (2012). Front Cover. (e) A. Onoda, A. Takahashi, K. Oohora, Y. Onuma, T. Hayashi, Chem. Biodivers., 1689 (2012).
2) (a) A. Onoda, Y. Ueya, T. Sakamoto, T. Uematsu, T. Hayashi, Chem. Commun., 9107 (2010). Front Cover. (b) A. Onoda, T. Himiyama, K. Ohkubo, S. Fukuzumi, T. Hayash, Chem. Commun., 48, 8054 (2012). (c) T. Himiyama, A. Onoda, T. Hayashi, Chem. Lett., 43, 1152–1154 (2014).
3) (a) A. Onoda, Y. Kakikura, T. Uematsu, S. Kuwabata, T. Hayashi, Angew. Chem. Int. Ed, 51, 2628 (2012). Hot Paper. (b) A. Onoda, Y. Kakikura, E. Kubo, H. Kitagishi, T. Uematsu, S. Kuwabata, T. Hayashi, J. Inorg. Organomet. Polym. Mater., 23, 172 (2013), (c) A. Onoda, Y. Kakikura, T. Hayashi, Dalton Trans., 42, 16102 (2013).
Department of Applied Chemistry, Graduate School of Engineering, Osaka University