Herve DESVAUX +33 1 64 50 13 65 Assistant: Mrs. Sylvie Allard-Ribetti, +33 1 64 50 15 75 Version française (moins détaillée) Web page of the laboratory NIMBE/LSDRM

Professional activity

• CEA Managing Director of programs
• Researcher in CEA since 1994
• Research director

Thema of Research

I am mainly involved in the development of NMR in order to allow better characterization of internal molecular dynamics and to improve the NMR signal through resorting to optically polarized noble gas. My main achievements are:

• Exploration of internal dynamics and structure of biomolecules
  - Development of a full methodology to study relaxation in the presence of off-resonance rf irradiation, useful for solution-structure determination more
         Headline ► Le glutathion, première défense contre les métaux lourds See also
  - Characterization of slow motions present in biomolecules more
  - New methods for measurements of cross-correlation cross-relaxation more
  - First use of mineral liquid crystals to align biomolecules
   
• Preparation and use of Laser-polarized xenon
  - Development of an optical pumping apparatus allowing the improvement of xenon polarization by a factor about 40 000. more
  - First polarization transfer from laser polarized xenon to proton of a cage molecule by cross-relaxation more
  - First characterization of hydrophobic protein cavities thanks to laser-polarized xenon more
  - Use of encapsulated laser-polarized xenon as a biosensor 
         Headline ► Toward a new molecular imaging using hyperpolarized 129Xe NMR biosensors
         Headline ► NMR detection of cellular internalization of hyperpolarized xenon: application to transferrin
  - First polarization transfer from xenon to proton using the distant dipolar fields more
  - Non linear dynamics with highly polarized and highy concentrated xenon solution more
         Headline ► Observation of noise-triggered chaotic emissions in an NMR-maser
  - Spin-noise measurements and optimal probe tuning more
         Headline ► Towards record levels of sensitivity for NMR by the measurement of spin-noise spectra
         Headline ► Introducing nuclear spin-noise spectroscopy: a complete analytical model for improved sensitivity

My current main activities concern the three last points that is the non-linear effects which can be observed in liquid-state NMR. This work is developped in collaboration with the groupes of P.J. Nacher at ENS (Paris) and N. Müller at Univ. J. Keppler (Linz, Austria). In 2013, a common projet, named IMAGINE for "NMR Investigation of MAGnetization-Induced Non-linear Effects" financed by ANR and FWF has been lanched (Austrian web site of the project). A SME, RS2D (Bischwiller, France) also collaborate with us.

The collaboration with N. Müller is also supported by bilateral collaboration project (Austria-France) "Effects of chemical exchange on NMR spectra at high nuclear spin polarisation". In this framework and thanks to the WTZ Amadée Award 2013, N. Müller and H. Desvaux have organized the 1^st Austrian-French NMR Symposium 2013 at the institut Français in the center of Vienna (19-20 September 2013).

Curiculum Vitae

• 2019-       Managing director. CEA delegated division to programs
• 2013-19 Director of IRAMIS
• 2011-15 Member of the Academic Senate of Paris-Saclay University
• 2009-13 Deputy-head of IRAMIS
• 1998 Habilitation to lead research
• 1995-96 Post-doctoral position in the National High Magnetic Field Laboratory, Tallahassee, Florida, Supervisor Pr. Geoffrey Bodenhausen
• 1993-94 Post-doctoral position in the Laboratoire de Physique des Solides, Orsay, Supervisor Dr. Patrick Batail
• 1990-93 Ph-D thesis in the Service de Chimie Moléculaire CEA/Saclay, Supervisor Pr. Maurice Goldman
• 1993 Ph-D thesis,
• 1988-92 Scholarship at the Ecole Normale Supérieure (Paris)

Publications

List of Publications

Teaching

• 2003-08 Courses of NMR in Master 2 at the University of Versailles
• 2003-05 Part-time Full Professor at the University of Evry-Val d'Essonne
• 1992-95 Courses at the Magistère Interuniversitaire de Paris

Awards

• 2013 : WTZ Amadée award with Pr. N. Müller
• 2001: ACI grant for young researcher
• 1994: Marie-Louise Arconati Visconti Prize

Former students

Master students:

• 2005 Sophie Béquignat
• 2001 Francisco Alvarez Salgado
• 1997 Marina Prischepa
• 1995 Nathalie Picqué
• 1993 Céline Landon

Ph-D students:

• 2005-08 Denis J.Y. Marion web page, Thesis, Award
• 2002-05 Francisco Alvarez Salgado

Post-doctoral students:

• 2009-11 Steven W. Morgan
• 2002-03 Lionel Dubois

Miscellaneous

Une petite histoire de la Résonance Magnétique Nucléaire: Conference given for the opening day of the 800MHz spectometer in Lille.

Principe et application de la Résonance Magnétique Nucléaire: Presentation prepared for the opening days of Neurospin.

Software and pulse program for real-time tuning according to the reception