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Polymer and hybrid nano-objects under irradiation

Contact: CARROT Géraldine - RENAULT Jean-Philippe, , geraldine.carrot@cea.fr, +33 1 69 08 21 49
Summary:
M1 or M2 level internship:
The project consists in the synthesis and the characterization of polymer nanoparticles from amphiphilic copolymers with one radiosensitive block. The other issue is to form metal nanoparticles (radiosensitizing effect) with a polymer corona. The objective is then to incorporate drugs inside these objects (by hydrophobic interactions or covalent grafting).
Possibility of continuation in PhD: Oui
Deadline for application:02/05/2018

Full description:
This project involves the development of new delivery systems for drugs based on the degradation of polymers by irradiation. This new stimulus has never been explored for such applications. This permits to consider a coupled chemo- and radiotherapy beyond the simple trigger release. So far, we have checked the feasibility of the process via experiments on various polymer films. Now, the objective is to perform the synthesis of a library of original amphiphilic copolymers, i.e. with a water-soluble/biocompatible part, together with a hydrophobic/radiosensitive part. The self-assembly into micelles or vesicles will lead to objects with a radiosensitive core where the drug will be located. The other strategy consists in the use of hybrid objects based on metallic nanoparticles (NPs) which increase the local radiation effect. The NPs will be either incorporated to the polymer micelle core, or functionalized with a polymer corona. The first advantage of these new systems is to control more finely the targeting of drug to the tumor cells and to avoid the side effects associated with chemotherapy and radiotherapy, by controlling the position of the irradiating beam and /or the absorbed doses.

Technics/methods used during the internship:
Polymer synthesis, organic chemistry, SEC, UV and FTIR spectroscopies, TGA, light scattering, etc...

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