Equilibrium reaction between the Unfolded ensemble and the Native state of a protein with or without crowding agent.
Following the synthesis by the ribosome, to carry out its biological function, a protein much fold into a single, well defined conformational state: the native state. Protein folding is thus the physico-chemical process by which a polypeptidic chain undergoes a structural change from an ensemble of coil like structure up to the unique structure encoded in its amino-acid sequence. This process is fascinating and remains one of the most challenging problems of structural biology. Protein misfolding is involved in number of pathologies such as BSE an Alzheimer diseases. More...
• Physique et chimie pour le vivant et l’environnement › Physique et vivant / Physics and life
• IRAMIS: Saclay Institute of Matter and Radiation • Laboratoire Léon Brillouin (LLB) • Leon Brillouin Laboratory (LLB)
• Biologie et Systèmes Désordonnés - GBSD (appareils 7C2, Paxe, Mibemol et Muse) • Disordered System and Biology - GSDB
• Neutrons • Diffractomètres de "diffusion de neutrons aux petits angles" : PACE, PA20, PAxy, TPA • Neutrons • Small Angle Neutron Scattering (PA)