| | | | | | | webmail : intra-extra| Accès VPN| Accès IST| Contact
Univ. Paris-Saclay
27 août 2019
Protein−Polymer Dynamics as Affected by Polymer Coating and Interactions
logo_tutelle logo_tutelle 
Protein−Polymer Dynamics as Affected by Polymer Coating and Interactions

Temperature dependence of mean square displacement of H atoms in 3 samples

D. Russo, A. De Angelis, A. Paciaroni, B. Frick, N. de Sousa, F. R. Wurm, and J. Teixeira

We investigate the relaxation dynamics of proteinpolymer conjugates by neutron scattering spectroscopy to understand to which extent the coating of a protein by a polymer can replace water in promoting thermal structural fluctuations. For this purpose, we compare the dynamics of proteinpolymer mixtures to that of conjugates with a variable number of polymers covalently attached to the protein. Results show that the flexibility of the protein is larger in proteinpolymer mixtures than in native protein or in conjugates, even in the dry state. Upon hydration, both the native protein and the conjugate show equivalent dynamics, suggesting that the polymer grafted on the protein surface adsorbs all water molecules.

http://dx.doi.org/10.1021/acs.langmuir.8b03636

 
#3150 - Màj : 27/08/2019

 

Retour en haut