ANR-12-BSV5-0003, coordination and contact Patrick Berthault - LSDRM.
This ambitious project aims at proposing the combined use of hyperpolarized 129Xe NMR, micro-fluidics and micro-coils as an ultra sensitive biosensing tool for diagnosis purposes.
The final objective of this project is to integrate all developments and discoveries in an NMR lab-on-chip type system of general applicability for various in vitro biological diagnoses on commercial NMR spectrometers.
Globally large efforts are dedicated to improve the sensitivity of NMR mainly via two complementary approaches:
However these developments entail the appearance of new phenomena related to the non-linear evolution of nuclear magnetization in liquid samples (See for instance for a review in this field).
In most cases they result from the intricate combination of:
These effects are actually met in a wide range of other physical systems (such as Bose-Einstein condensates, superfluid 3He, or quantum entangled spin systems).