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Univ. Paris-Saclay

Sujet de stage / Master 2 Internship

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Hyphenation of digital microfluidic with inductively coupled plasma mass spectrometry

Contact: GEERTSEN Valerie, , valerie.geertsen@cea.fr, +33 6 43 36 05 45
Summary:
This internship studies the fabrication of a microfluidic droplet generator coupled to an ICPMS mass spectrometer. This system is dedicated to the encapsulation and the analysis of single nanoparticle (SPICPMS).
Possibility of continuation in PhD: Non
Deadline for application:30/04/2022

Full description:
The internship focuses on the development of a new instrumental hyphenation associating digital microfluidic platform with inductively coupled plasma mass spectrometer (µDig-ICPMS). It will be supervised by the LIONS laboratory of CEA Saclay (DRF/LIONS).
These last years have seen in several laboratories around the world such as DRF/LIONS, the development of microfluidics platforms to create and manipulate calibrated liquid droplets inside a continuous liquid phase (µDig). These platforms are relevant not only for low-sample or low-waste volumes analysis but also for new analytical concepts such as heterogeneous samples analysis (determination of objects population).
The internship purpose is to fabricate microfluidic chips to generate water droplets of predefined-size inside a continuous oil phase and study its hyphenation with the mass spectrometer ionization source.
Internship duration is at least 6 months. This interdisciplinary thematic requires team work ability, large scientific curiosity and openness. Instrumentation being a large component of this study, the candidate must show a commitment for experimental laboratory work. A competence in microfabrication or analytical chemistry will be fully appreciated.
Technics/methods used during the internship:
3D printing, lithography, ICPMS, python

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