Laboratoire Léon Brillouin

UMR12 CEA-CNRS, Bât. 563 CEA Saclay

91191 Gif sur Yvette Cedex, France


Let's scatter neutrons

Apr 07, 2024
Nina Královič-Kanjaková, Ali Asi Shirazi, Lukáš Hubčík, Mária Klacsová, Atoosa Keshavarzi, Juan Carlos Martínez, Sophie Combet, José Teixeira, and Daniela Uhríková The use of an exogenous pulmonary surfactant (EPS) to deliver other relevant drugs to the lungs is a promising strategy for combined therapy.
Dec 01, 2023
Anne-Charlotte Le Gulluche, Guylaine Ducouret, Ludovic Olanier, Annie Brûlet, Olivier Sanseau, Paul Sotta, and Alba Marcellan Model hybrid hydrogels reinforced by silica nanoparticles were designed by polymerizing and cross-linking the gels in situ. The polymer–particle interactions were tuned by using either poly(dimethylacrylamide) (PDMA), which adsorbs on silica, or poly(acrylamide) (PAAm), which does not.
Jul 06, 2023
Simeon Minic, Burkhard Annighöfer, Milos Milcic, François Maignen, Annie Brûlet, Sophie Combet Apomyoglobin (apoMb), a model protein in biochemistry, exhibits a strong propensity to bind various ligands, which makes it a good candidate as a carrier of bioactive hydrophobic drugs. The stability of its hydrophobic pocket determines its potential as a carrier of bioactive compounds.
Jun 13, 2023
Somia Haouache, Yu Chen, Clara Jimenez-Saelices, Fabrice Cousin, Pan Chen, Yoshiharu Nishiyama, François Jerome, and Isabelle Capron Nanocelluloses can be used to stabilize oil–water surfaces, forming so-called Pickering emulsions. In this work, we compare the organization of native and mercerized cellulose nanocrystals (CNC-I and CNC-II) adsorbed on the surface of hexadecane droplets dispersed in water at different CNC concentrations.
May 23, 2023
Özge Azeri, Dennis Schönfeld, Bin Dai, Uwe Keiderling, Laurence Noirez and Michael Gradzielski Block copolymers synthesized via Atom Transfer Radical Polymerization from alkyl acrylate and t-butyl acrylate and the subsequent hydrolysis of the t-butyl acrylate to acrylic acid were systematically varied with respect to their hydrophobic part by the variation in the alkyl chain length and the degree of polymerisation in this block.
May 02, 2023
Céline JAUDOIN, Isabelle GRILLO, Fabrice COUSIN, Maria GEHRKE, Malika OULDALI, Ana-Andreea ARTENI, Luc PICTON, Christophe RIHOUEY, Fanny SIMELIERE, Amélie BOCHOT, Florence AGNELY Mixtures of hyaluronic acid (HA) with liposomes lead to hybrid colloid–polymer systems with a great interest in drug delivery. However, little is known about their microstructure.
Apr 08, 2023
Anne-Sophie Robbes, Jacques Jestin, Florian Meneau, Florent Dalmas, François Boué, and Fabrice Cousin, Macromolecules 2022, 55, 15, 6876–6889.
Jan 27, 2023
Sophie Combet, Françoise Bonneté, Stéphanie Finet, Alexandre Pozza, Christelle Saade, Anne Martel, Alexandros Koutsioubas, Jean-Jacques Lacapère, Biochimie (2022) in press.   The translocator protein (TSPO) is a ubiquitous transmembrane protein of great pharmacological interest thanks to its high affinity to many drug ligands.
Oct 17, 2022
I. Mirebeau et N. Martin, J. Appl. Cryst. (2022). 55, 1173-1183 The application is discussed of neutron methods to the study of reentrant spin glasses (RSGs), close to the transition towards a `canonical' spin glass (SG). The focus is on two emblematic systems, namely Au1−xFex and amorphous a-Fe1−xMnx. A set of experimental results is presented to highlight their peculiar static and dynamic properties.
Sep 02, 2022
Simeon Minić, Burkhard Annighöfer, Arnaud Hélary, Laïla Sago, David Cornu, Annie Brûlet, Sophie Combet High pressure (HP) is a particularly powerful tool to study protein folding/unfolding, revealing subtle structural rearrangements. Bovine β-lactoglobulin (BLG), a protein of interest in food science, exhibits a strong propensity to bind various bioactive molecules.
Jul 01, 2022
Tiago Outerelo Corvo, Antoine Jourdain, Shona O’Brien, Frédéric Restagno, Eric Drockenmuller, and Alexis Chennevière Poly(ionic liquid)s (PILs), similar to their ionic liquid (IL) analogues, present a nanostructure arising from local interactions.
Jun 02, 2022
Marion Grzelka, Iurii Antoniuk, Éric Drockenmuller, Alexis Chennevière, Liliane Léger, and Frédéric Restagno The role of the polymer volume fraction, ϕ, on steady-state slippage and interfacial friction is investigated for semi-dilute polystyrene solutions in diethyl phthalate in contact with two solid surfaces. Significant slippage is evidenced for all samples, with slip lengths b obeying a power law dependence.
Apr 21, 2022
Sumit Mehan, Laure Herrmann, Jean-Paul Chapel, Jacques Jestin, Jean-Francois Berret and Fabrice Cousin We investigate the formation/re-dissociation mechanisms of hybrid complexes made from negatively charged PAA2k coated g-Fe2O3 nanoparticles (NP) and positively charged polycations (PDADMAC) in aqueous solution in the regime of very high ionic strength (I).
Feb 22, 2022
J.C.Riedl, M.Sarkar, T.Fiuza, F.Cousin, J.Depeyrot, E.Dubois,G.Mériguet,R.Perzynski and V.Peyre Some of the most promising fields of application of ionic liquid-based colloids imply elevated temperatures. Their careful design and analysis is therefore essential. We assume that tuning the structure of the nanoparticle-ionic liquid interface through its composition can ensure colloidal stability for a wide temperature range, from room temperature up to 200 °C.
Dec 15, 2021
Virginie Vergnat, Benoît Heinrich, Michel Rawiso, René Muller, Geneviève Pourroy and Patrick Masson Embedding nanoparticles (NPs) with organic shells is a way to control their aggregation behavior. Using polymers allows reaching relatively high shell thicknesses but suffers from the difficulty of obtaining regular hybrid objects at gram scale.
Sep 18, 2021
T. Fiuza, M. Sarkar, J. C. Riedl, A. Cebers, F. Cousin, G. Demouchy, J. Depeyrot, E. Dubois, F. Gelebart, G. Meriguet, R. Perzynski and V. Peyre Ferrofluids based on maghemite nanoparticles (NPs), typically 10 nm in diameter, are dispersed in an ionic liquid (1-ethyl 3-methylimidazolium bistriflimide – EMIM-TFSI). The average interparticle interaction is found to be repulsive by small angle scattering of X-rays and of neutrons, with a second virial coefficient A2 = 7.3.
Jul 21, 2021
Sebastian Jaksch, Alexis Chennevière, Sylvain Désert, Tadeusz Kozielewski, Herbert Feilbach, Pascal Lavie, Romuald Hanslik, Achim Gussen, Stephan Butterweck, Ralf Engels, Henrich Frielinghaus, Stephan Förster and Peter Müller-Buschbaum Small-K Advanced DIffractometer (SKADI is a Small-Angle Neutron Scattering (SANS) instrument to be constructed at the European Spallation Source (ESS).
Dec 02, 2020
Simeon Minic, Burkhard Annighofer, Arnaud Helary, Djemel Hamdane, Gaston Hui Bon Hoa, Camille Loupiac, Annie Brulet, and Sophie Combet To probe intermediate states during unfolding and oligomerization of proteins remains a major challenge. High pressure (HP) is a powerful tool for studying these problems, revealing subtle structural changes in proteins not accessible by other means of denaturation.
Nov 10, 2020
Chang Liu, Wenxian Hu, Hanqiu Jiang, Guoming Liu*, Charles C. Han, Henning Sirringhaus, François Boué, and Dujin Wang The determination of intrinsic chain stiffness of conjugated polymers is challenging, in particular, for scattering techniques because of their strong light absorption and structural instability due to the complicated intra-/intermolecular interactions.
Sep 28, 2020
Li Shi, Florent Carn, Arsen Goukassov, Eric Buhler, and François Boué Mixing negatively charged polyelectrolyte (PEL) with positively charged gold nanoparticles (Au NPs) in aqueous solution results in electrostatics complexes of different shapes and compactness. Here, when complexing with a semirigid PEL hyaluronic acid (HA), we obtain crystals made of nanoparticles in a new region of the phase diagram, as evidenced by small-angle Xray scattering (SAXS).
Sep 02, 2020
Marine Le Goas, Tom Roussel, Maria Kalbazova, David Carrière, Elodie Barruet, Valerie Geertsen, Giulia C. Fadda, Fabienne Testard, Geraldine Carrot and Jean-Philippe Renault Nanomedicines are considered as promising therapeutics for cancer treatment. However, clinical translation is still scarce, partly because their biological behavior is not well understood.
Jun 23, 2020
We show by X-ray and neutron small-angle scattering that gold nanoparticles with controlled sizes and morphologies can be obtained by the metallic reduction of AuCl4– ions trapped in 3D organic molds by X-ray radiolysis. The molds are spherical frozen micelles of polystyrene-b-poly(dimethylaminoethyl methacrylate) (PS-b-PDMAEMA) block copolymer in acidic aqueous solution with a PS spherical core surrounded by a corona of PDMAEMA chains in good solvent.
May 09, 2020
Andrew M. Jimenez, Dan Zhao, Kyle Misquitta, Jacques Jestin and Sanat K. Kumar Understanding the structure and dynamics of the bound polymer layer (BL) that forms on favorably interacting nanoparticles (NPs) is critical to revealing the mechanisms responsible for material property enhancements in polymer nanocomposites (PNCs).
Apr 08, 2020
Aline Maire du Poset, Mikaela Börjesson, Céline Rameau, Claire Madeleine-Perdrillat, Adrien Lerbret, Camille Loupiac, Fabrice Cousin, Ali Assifaoui We show here how the structure of polygalacturonate (polyGalA) hydrogels cross-linked by Ca2+ cations via external gelation controls the loading and release rate of beta-lactoglobulin (BLG), a globular protein.
Feb 13, 2020
de Oliveira-Silva, Rodrigo; Bélime, Agathe; Le Coeur, Clémence; Chennevière, Alexis; Helary, Arnaud; Cousin, Fabrice; Judeinstein, Patrick; Sakellariou, Dimitrios; Zanotti, Jean-Marc In soft condensed matter, Small Angle Neutron Scattering (SANS) is a central tool to probe structures with characteristic sizes ranging from 1 to 100 nm. However, when used as a standalone technique, the dynamic properties of the sample are not accessible.
Nov 25, 2019
A. S. Sukhanov, Praveen Vir, A. S. Cameron, H. C. Wu, N. Martin, S. Mühlbauer, A. Heinemann, H. D. Yang, C. Felser, and D. S. Inosov The cubic chiral helimagnets with the P213 space group represent a group of compounds in which the stable skyrmion-lattice state is experimentally observed. The key parameter that controls the energy landscape of such systems and determines the emergence of a topologically nontrivial magnetic structure is the Dzyaloshinskii-Moriya interaction (DMI).
Jun 20, 2019
A. Theodoratou, L.-T. Lee, J. Oberdisse and A. Aubert-Pouëssel, Langmuir 35(20) (2019) 6620. Abstract : Nanofilms of about 2 nm thickness have been formed at the air–water interface using functionalized castor oil (ICO) with cross-linkable silylated groups.
May 04, 2019
B. Annighöfer , A. Hélary, A. Brulet, A. Colas de la Noue, C. Loupiac and S. Combet Review of Scientific Instruments 90 (2019) 025106 Abstract : We report on a high pressure (HP) cell designed for the determination of the structure of molecular solutions by small-angle neutron scattering (SANS). The HP cell is fitted up with two thick metallic windows that make the device very resistant under hydrostatic pressures up to 600 MPa (or 6 kbar).
Mar 05, 2019
Annelies Sels, Giovanni Salassa, Fabrice Cousin, Lay-Theng Lee, Thomas Bürgi, Nanoscale 26 (2018) 12754. Aromatic dithiol linkers were used to prepare aggregates of Au25(SR)18 clusters (SR: thiolate) via ligand exchange reactions. Fractions of different aggregate sizes were separated by size exclusion chromatography (SEC).
Mar 04, 2019
Marguerite Léang, Didier Lairez, Fabrice Cousin, Frédérique Giorgiutti-Dauphiné, Ludovic Pauchard, Lay-Theng Lee During evaporative drying of a colloidal dispersion, the structural behavior at the air-dispersion interface is of particular relevance to the understanding of the consolidation mechanism and the final structural and mechanical properties of the porous media.
Feb 15, 2019
Burkhard Annighöfer, Arnaud Hélary, Annie Brûlet, Alexandre Colas de la Noue, Camille Loupiac, and Sophie Combet We report on a high pressure (HP) cell designed for the determination of the structure of molecular solutions by small-angle neutron scattering (SANS). The HP cell is fitted up with two thick metallic windows that make the device very resistant under hydrostatic pressures up to 600 MPa (or 6 kbar).
Dec 12, 2018
Souha Ben Mahmoud, Wafa Essafi, Annie Brûlet and François Boué The chain conformation in sulfonated polystyrene PSSNa of a degree of sulfonation 0.34 ≤ f ≤ 1, i.e., of various hydrophobicity, is followed in mixtures of water and increasing content of tetrahydrofuran (THF), a good solvent of the hydrophobic polystyrene moieties (which improves the solvent quality of the mixture).
Nov 20, 2018
Jyotsana Lal This article is dedicated to the memory of Loic Auvray The results on Winsor phases, droplet and bicontinous microemulsions phases with polymer-grafted lipids studied by Small Angle Neutron Scattering (SANS) are reported below, together with the contrast variation techniques used to characterize the average curvature in the system.
Oct 15, 2018
Raphael Dos Santos Morais, Olivier Delalande, Javier Perez, Dominique Mias-Lucquin, Melanie Lagarrigue, Anne Martel, Anne-Elisabeth Molza, Angelique Cheron, Celine Raguenes-Nicol, Thomas Chenuel, Arnaud Bondon, Marie-Sousai Appavou, Elisabeth Le Rumeur, Sophie Combet, and Jean-Francois Hubert Scaffolding proteins play important roles in supporting the plasma membrane (sarcolemma) of muscle cells.
Sep 24, 2018
Fengjiao Qian, Lars J. Bannenberg, Heribert Wilhelm, Grégory Chaboussant, Lisa M. Debeer-Schmitt, Marcus P. Schmidt, Aisha Aqeel, Thomas T. M. Palstra, Ekkes Brück, Anton J. E. Lefering, Catherine Pappas, Maxim Mostovoy, Andrey O.
Aug 29, 2018
I. Mirebeau, N. Martin, M. Deutsch, L. J. Bannenberg, C. Pappas, G. Chaboussant, R. Cubitt, C. Decorse, and A. O. Leonov Reentrant spin glasses are frustrated disordered ferromagnets developing vortexlike textures under an applied magnetic field. Our study of a Ni0.81Mn0.19Ni0.81Mn0.19 single crystal by small angle neutron scattering clarifies their internal structure and shows that these textures are randomly distributed.
Aug 09, 2018
Maelenn Chevreuil, Didier Law-Hine, Jingzhi Chen, Stéphane Bressanelli, Sophie Combet, Doru Constantin, Jéril Degrouard, Johannes Möller, Mehdi Zeghal and Guillaume Tresset The survival of viruses partly relies on their ability to self-assemble inside host cells. Although coarse-grained simulations have identified different pathways leading to assembled virions from their components, experimental evidence is severely lacking.
Apr 17, 2018
Structural characterization of nanoparticles formed by fluorinated poly(2-oxazoline)-based polyphiles, Anna Riabtseva, Leonid I. Kaberov, Laurence Noirez, Vasyl Ryukhtin, Corinne Nardin, Bart Verbraeken, Richard Hoogenboom, Petr Stepanek, Sergey K. Filippov, European Polymer Journal 99 (2018) 518.
Oct 26, 2017
Raphael Dos Santos Morais, Olivier Delalande, Javier Pérez, Liza Mouret, Arnaud Bondon, Anne Martel, Marie-Sousai Appavou, Elisabeth Le Rumeur, Jean-François Hubert, and Sophie Combet Obtaining structural information on integral or peripheral membrane proteins is currently arduous due to the difficulty of their solubilization, purification, and crystallization (for X-ray crystallography (XRC) application).


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