Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful tool for biology, allowing structural and chemical analysis of metabolites as well as imagery (MRI). A collaboration of scientists from Nimbe, Neurospin and Bordeaux University, has recently designed a non-invasive online NMR μ-probe for profiling in-vivo metabolic physiological activities with a micro-size NMR detector placed in "close proximity" to a microdialysis sampling probe.