Access: located on the Saclay site of the Commissariat à l'Energie Atomique (CEA), 20 km south of Paris, France : map (pdf), how to come (pdf).
ALIENOR is the main experimental platform of the Laboratoire de Radiolyse. It is a linear accelerator delivering nanosecond to microsecond pulses of 10 MeV electron beam with a repetition rate up to 100 Hz. ALIENOR is a world-class research infrastructure providing state-of-the-art nanosecond to microsecond pulse radiolysis experimental setups, such as UV-visible-NIR transient absorption and fluorescence spectrometers, high-pressure/high temperature flow cell devoted to liquid and supercritical water studies, in line FT-IR spectrophotometer and high throughput spectroscopy (see activity report).
The Laboratoire de Radiolyse with the use of ALIENOR develops research activities in the following areas: primary events, interfaces and confined media, extreme pressure and temperature conditions and radiation biochemistry. Concerning the primary events, the Laboratoire de Radiolyse focuses especially on understanding the influence of parameters such as temperature, pressure, the role of the H-bond network and the linear energy transfer (LET) of the ionising particles. The Laboratoire is also developping new approaches to understand the radiolysis of water in nanoporous media and at interfaces. The development of FT-IR spectroscopy is connected to this field. The Laboratoire de Radiolyse studies effects of pressure and temperature in water radiolysis, especially in supercritical water. In the radiation biochemistry, the molecular mechanisms inside the living cell remains difficult to understand and are investigated. Water radiolysis is then used to mimic the toxicity conditions.
The characteristics of ALIENOR together with the conditions are given in the Table below.
ALIENOR |
CEA-Saclay |
Laboratoire de Radiolyse |
Medical Radiation Habilitation is necessary. User Category B for radiation habilitation. |
Dosimeter film is compulsory and provided by the user's institution. A local user dosicard is provided by CEA and is only used in the vicinity of ALIENOR. |
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Schedule is discussed every 2-3 months in a laboratory meeting. |
Scientific collaboration is needed with the local contact. |
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Biological and FT-IR installations access on demand and depending on the planning. |
Experiment unit time: 1 week (5 days, 7 hours a day) |
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ELECTRON BEAM CHARACTERISTICS |
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Pulsed electron beam |
Predefined and measured energies: 8, 9 or 10 MeV |
Pulse duration (repetition rate): * 10 ns (up to 100 Hz) * 5 µs (up to 1 Hz)-single shot |
Charge per pulse |
Up to 50 nC (at 10 ns) and to 1000 nC (at 1 µs) |
Up to 6 1012 electrons per pulse |
| Dosimetry: chemical (SCN-, Fricke) | Around 20 Gy for a 10 ns pulse in 2 mm thick of liquid water |
Real time current measured with beam current monitors (BCM) |
IRRADIATION ENVIRONMENT |
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No scanning available |
No heavy material in the beam |
Irradiated surface: around 1 cm2 |
The ALIENOR platform can thus be used for the following experiments: in line FT-IR spectroscopy (see Figure below), high-pressure high-temperature flow cell, in line H2 measurements (gas chromatography)...
Figure: Picture of the in-line FT-IR experiment.
Recent references from Laboratoire de Radiolyse:
2007:
S. Le Caër, G. Vigneron, J. P. Renault and S. Pommeret, “Radiolysis of ferrocyanide solutions studied by infrared spectroscopy”, Radiation Physics and Chemistry, 2007, 76, 1280.
S. Le Caër, J. Palmer, M. Lima, J.P. Renault, G. Vigneron, R. Righini, S. Pommeret, “Time-resolved studies of water dynamics and proton transfer at the alumina-air interface”, Journal of the American Chemical Society, 2007, 129, 11720.
G. Mousseau, O.P. Thomas, S. Oppiliart, A. Coirier, A. Salcedo-Serna, R.Thai , F. Beau, J.P. Renault, S. Pin, J.-C. Cintrat, B. Rousseau, "Localization and quantification of carbon-centered radicals on any amino acid of a protein", Analytical Chemistry, 2007, 79, 5444-5448.
M. Molin, J.P. Renault, G. Lagniel, S. Pin, M. Toledano, J. Labarre, "Ionizing
radiation induces a Yap1-dependent peroxide stress response in yeast",
Free Radical Biology and Medecine, 2007, 43,
136-144.
2006:
G. Baldacchino, G. Vigneron, J.P. Renault, S. Le Caër, S. Pin, J.-C. Mialocq, E. Balanzat, S. Bouffard, "Hydroxyl radical yields in the tracks of high energy 13C6+ and 36Ar18+ ions in liquid water", Nuclear Instruments and Methods in Physics Research B, 2006, 245, 288-291.
M. Taguchi, Y. Zennyoji, M. Takigami, G. Baldacchino, A. Kimura, H. Hiratsuka, H. Namba, T. Kojima, "Characteristics study on suspended fine particles in aqueous phenol solution formed by electronbeam irradiations", Radiation Physics and Chemistry, 2006, 75, 564-571.
G. Baldacchino, M. Taguchi, S. Pin, G. Vigneron, S. Bouffard, S. Pommeret, B. Hickel, "Formation of superoxide radical in the tracks of liquid water under high energy heavy ion irradiation. A pulse radiolysis study", Indian Journal of Radiation Research, 2006, 3(2-3), 113-116.
G. Baldacchino, V. de Waele, H. Monard, S. Sorgues, F. Gobert, J.P. Larbre, G. Vigneron, J.L. Marignier, S. Pommeret, M. Mostafavi, "Hydrated electron decay measurements with picosecond pulse radiolysis at elevated temperatures up to 350°C", Chemical Physics Letters, 2006, 424, 77-81.
S. Le Caër, G. Vigneron, J. P. Renault, S. Pommeret, “First coupling between a LINAC and FT-IR spectroscopy: the aqueous ferrocyanide system”, Chemical Physics Letters, 2006, 426, 71.
D. Simeone, G. Baldinozzi, D. Gosset, S. Le Caër, “Phase transition of pure zirconia under irradiation: A textbook example”, Nuclear Instruments and Methods in Physics Research B, 2006, 250, 95.
G. Baldinozzi, D. Simeone, D. Gosset, I. Monnet, S. Le Caër, L. Mazerolles, ”Evidence of extended defects in pure zirconia irradiated by swift heavy ions”, Physical Review B, 2006, 74, 132107.
R. Comanici, B. Gabel, T. Gustavsson, D. Markovitsi, C. Cornaggia, S. Pommeret, C. Rusu, C. Kryschi, "Femtosecond spectroscopic study of carminic acid–DNA interactions", Chemical Physics, 2006, 325 (2-3), 509-518.
B. Soroushian, I. Lampre, J. Bonin, P. Pernot, S. Pommeret, M. Mostafavi, "Solvation Dynamics of the Electron Produced by Two-Photon Ionization of Liquid Polyols. 1. Ethylene Glycol", Journal of Physical Chemistry A, 2006, 110 (5), 1705 -1717.
C. Loupiac, M. Bonetti, S. Pin, P. Calmettes, "ß-lactoglobulin under high pressure studied by small-angle neutron scattering", Biochimica Biophysica Acta, Proteins and Proteomics, 2006, 1764, 211-216.
2005:
S. Foley, P. Rotureau, S. Pin, G. Baldacchino, J.-P. Renault, J.-C. Mialocq, "Radiolysis of confined water : production and reactivity of hydroxyl radical", Angewandte Chemie – International Edition, 2005, 44, 110-112.
C. Bataille, G. Baldacchino, R.P. Cosson, M. Coppo, C. Trehen, G. Vigneron, J.P. Renault, S. Pin, "Effect of Pressure on Pulse Radiolysis Reduction of Proteins", Biochimica Biophysica Acta, General Subjects, 2005, 1724, 432-439.
S. Le Caër, P. Rotureau, F. Brunet, T. Charpentier, G. Blain, J. P. Renault, J.-C. Mialocq, “Radiolysis of confined water: Hydrogen production at a high dose rate”, ChemPhysChem, 2005, 6, 2585.
G. Baldacchono, G. Vigneron, S. Pin, S. Pommeret, "Etudes cinétiques des réactions chimiques radicalaires dans l'eau supercritique", Outils et méthodes pour le recherche à haute pression, CNRS Editions, 2005, 229-233.
C. Loupiac, M. Bonetti, S. Pin, P. Calmettes, "Mesures de diffusion de neutrons aux petits angles pour étudier l'effet des hautes pressions sur la structure des protéines globulaires", Outils et méthodes pour le recherche à haute pression, CNRS Editions, 2005, 82-86.
S. Meunier, M. Hanedanian, M. Desage-El Murr, S. Nowaczyk, T. Le Gall, S. Pin, J.P. Renault, D. Boquet, C. Creminon, C. Mioskowski, F. Taran, "High-throughput evaluation of antioxidant and pro-oxidant activities of polyphenols with thymidine protection assays", ChemBioChem, 2005, 6, 1234-1241.
G. Louit, S. Foley, J. Cabillic, H. Coffigny, F. taran, A. Valleix, J.P.
Renault, S. Pin, "The
reaction of coumarin with the OH radical revisited: hydroxylation product
analysis determined by fluorescence and chromatography",
Radiation Physics and Chemistry, 2005, 72,
119-124.
S. Durot, C. Policar, F. Cisnetti, F. Lambert, J.P. Renault, G. Pelosi, G. Blain, H. Korri-Youssoufi, J.P. Mahy, "Series of Mn complexes based on N-centered ligands and superoxide - Reactivity in an anhydrous medium and SOD-like activity in an aqueous medium correlated to MnII/MnIII redox potentials", European Journal of Inorganic Chemistry, 2005, 2005 (17), 3513-3523.
S. Durot, F. Lambert, J.P. Renault, C. Policar, "A pulse radiolysis study of catalytic superoxide radical dismutation by a manganese(II) complex with an N-tripodal ligand", European Journal of Inorganic Chemistry, 2005, 2005 (14), 2789-2793.
P. Rotureau, J.P. Renault, B. Lebeau, J. Patarin, J.-C. Mialocq, "Radiolysis of confined water: Molecular hydrogen formation", ChemPhysChem, 2005, 6, 1316-1323.
A. Reboli, J. Aupiais, J.-C. Mialocq, "Application of large area avalanche photodiodes for alpha liquid scintillation counting", Nuclear Instruments and Methods in Physics Research Section A, 2005, 550, 593-602.
2004:
G. Baldacchino, G. Vigneron, J.-P. Renault, S. Pin, Z. Abedinzadeh, S. Deycard, E. Balanzat, S. Bouffard, M. Gardès-Albert, B. Hickel, J.-C. Mialocq, "A nanosecond pulse radiolysis study of the hydrated electron with high energy ions with a narrow velocity distribution", Chemical Physics Letters, 2004, 385, 66-71.
D. Simeone, G. Baldinozzi, D. Gosset, S. LeCaër, L. Mazerolles, "Impact of radiation defects on the structural stability of pure zirconia", Physical Review B, 2004, 70, 134116.
S. Bratos, J.-Cl. Leicknam, S. Pommeret, G. Gallot, "Laser spectroscopic visualization of hydrogen bond motions in liquid water", Journal of Molecular Structure, 2004, 708 (1-3), 197-203.
R. A. Crowell, R. Lian, I. A. Shkrob, J. Qian, D. A. Oulianov, S. Pommeret, "Light-Induced Temperature Jump Causes Power-Dependent Ultrafast Kinetics of Electrons Generated in Multiphoton Ionization of Liquid Water", Journal of Physical Chemistry A, 2004, 108 (42), 9105 -9114.
L. Zhao, R. Lian, I. A. Shkrob, R. A. Crowell, S. Pommeret, E. L. Chronister, A. D. Liu, A. D. Trifunac,"Ultrafast Studies on the Photophysics of Matrix-Isolated Radical Cations of Polycyclic Aromatic Hydrocarbons", Journal of Physical Chemistry A, 2004, 108 (1), 25 -31.
B. Soroushian, I. Lampre, P. Pernot, V. De Waele, S. Pommeret, Mehran Mostafavi, "Formation and geminate recombination of solvated electron upon two-photon ionisation of ethylene glycol", Chemical Physics Letters, 2004, 394 (4-6), 313-317.
S. Meunier, M. Desage-El Murr, S. Nowaczyk, T. Le Gall, S. Pin, J.P. Renault, D. Boquet, C. Creminon, E. Saint-Aman, A. Valleix, F. Taran, C. Mioskowski, "A powerful antiradiation compound revealed by a new high-throughput screening method", ChemBioChem, 2004, 5, 832-840.
