Patrick
GUENOUN
Research director,
Director of the PhOM pole of the Graduate School of Physics
(University Paris Saclay)
Member of the Laboratoire sur l'Organisation Nanométrique et
Supramoléculaire (LIONS)
Member of the Academic Board of University Paris Saclay (Research
council)
NIMBE, C.E.A. Saclay, 91191 Gif sur Yvette Cedex, France
Phone: (33)-01-69-08-74-33
Research interests
- Polymers and polyelectrolytes at interfaces,
charged
brushes,
-Polymers in solution,
water soluble polymers,
micelles, surfactants. 3D printing of polymer
- Wetting, thin films and adsorption. Block copolymer films
-Biomineralization:
nacre modeling and amyloid-like
peptides
- Critical phenomena in fluids and polymer solutions, phase
separation, thermal transport .
- Experimental techniques : scattering, atomic force microscopy,
optics.
Education
1979 Ecole Normale Supérieure (Cachan)
1982 Agrégation of Physics, Physics
1984-1987 PhD (Physics) Université Paris VI (Physics)
“Instability of fluid mixtures, influence of gravity forces
and wetting”,
1998 Habilitation à diriger des recherches, Université Paris VI
Employment
1987-2003 Permanent staff member at the Service de Physique
de l'Etat Condensé, C.E.A. Saclay
1991-1992 Research Associate at the Department of Chemical
Engineering and Materials Science
with M. Tirrell (University of Minnesota, Minneapolis (1991-1992))
2003- Permanent staff member at the LIONS, C.E.A. Saclay
Professional
activities
-Member of the Scientific Committee of the Laboratoire Léon
Brillouin (1999-2001 )
-President of the Condensed Matter Sciences Group of C.N.E.S.
(Centre national d’Etudes Spatiales)
-Member of the MAP panel of the European Space Agency (E.S.A.
2004-2005)
-Member of the Physical Sciences Advisory Group of E.S.A.
-Member of the "Soft matter" committee at Institute Laüe-Langevin
(ILL) (2008-2011)
-Member of the selection committee at E.S.R.F. (2012-2014)
-Nanochemistry responsible with C. Petit of DIM Nano'K Ile de
France (2013-2017)
-In charge of the "Complex Matter and Systems" group of the
Physics Department (PHOM) of University Paris Saclay (2014-)
-Head of Laboratoire sur l'Organisation Nanométrique et
Supramoléculaire (LIONS) ( 2010-2019)
-Director of the PhOM pole of the Graduate School of Physics
(University Paris Saclay) (2022-
On-going projects
1) Phase separation of
concentrated polymer water solutions: how to make
''green'' membranes without organic solvent ?
A PhD funding is available for a project involving
polyelectrolytes and their phase separation behavior, leading to
polyimide membranes making, take a look here (en français ici).
By using water-soluble
polymers with a miscibility gap, phase-separated structures like
interconnected spinodal-like decompositions can be turned in
membranes after a cross-linking process and evaporation of
solvent ( M'barki, O.; Hanafia, A.;
Bouyer, D.; Faur, C.; Sescousse, R.; Delabre, U.; Blot, C.;
Guenoun, P.; Deratani, A.; Quemener, D. & Pochat-Bohatier,
C., Greener method to prepare porous polymer membranes by
combining thermally induced phase separation and crosslinking
of poly (vinylalcohol) in water,JOURNAL OF MEMBRANE
SCIENCE, (2014), {458}, (225-235). https://dx.doi.org/10.1016/j.memsci.2013.12.013
This was the
subject of a
ANR CD2I project with IEM (Montpellier) and another ANR
project "Gaspom" (
GASPOM)
with IEM Montpellier (D. Bouyer coordinator), Polymem, Total is
running to know: how to make polymer membranes filtering and
resisting at high temperatures ?
Theoretical results of phase
separation adapted to concentrated polymer solutions for making
membranes can be obtained by adapted phase field methods, see: https://dx.doi.org/10.1016/j.ces.2017.08.009
Such methods can be extended to deal with fabrication methods of
membranes by evaporation of solvent, see: JMS
A post-doc position is opened for observing and characterizing
phase separation (PS) patterns of polymer solutions resulting
from Thermally Induced PS (TIPS) and Non Solvent Induced PS
(NIPS), see here for details.
2) Omniphobic surfaces
without fluor:
Fluor-based molecules can be replaced on surfaces while
keeping an omniphobic character: adorption of biosourced
molecules or silicone-grafting can lead to very efficient
slipping of drops:
PhD thesis projet of Marion Callau
An on-going extension of this work deals with making
textile fibers omnirepellent for oils and water without
using fluorine-molecules:
see a Post-doc or CDD offer here
3)
Invertible and multiple emulsions : how to form
one-step, stable multiple emulsions ?
Multiple emulsions, like water in oil in water drops, usually need
two surfactants (one for each interface) and are barely stable. By
using block copolymers with a hydrophobic moiety and a
thermosensitive hydrophilic charged moiety (like in
Marchal F, Roudot A, Pantoustier N, et
al. JOURNAL OF PHYSICAL CHEMISTRY B Volume:
111 Issue: 46 Pages: 13151-13155 (2007),
http://dx.doi.org./10.1021/jp0749827), things
change a lot: a single molecule is enough to stabilize for months
multiple emulsions in a range of pHs (
Besnard, L.; Marchal, F.;
Paredes, J. F.; Daillant, J.; Pantoustier, N.; Perrin,
P. & Guenoun, P. Multiple Emulsions Controlled by
Stimuli-Responsive Polymers, ADVANCED MATERIALS, (2013),
25, 2844-2848).
How far this is due to polymer conformation at the oil-water
interface is explained in
Besnard,
L.; Protat, M.; Malloggi, F.; Daillant, J.; Cousin,
F.; Pantoustier, N.; Guenoun, P. & Perrin, P.,
Breaking of the Bancroft rule for multiple emulsions
stabilized by a single stimulable polymer, SOFT
MATTER, (2014), 10, 7073-7087
where first successful trials of neutron reflectivity
at liquid-liquid interface are depicted.
http://dx.doi.org/10.1039/C4SM00596A
This was recently refined by further analysis in
http://dx.doi.org/10.1140/epje/i2018-11693-8
Recent advances are about the making of biocompatible
polymers for performing a similar job and about how salt addition
is able to control where multiple emulsions form
Protat, M.; Bodin, N.; Gobeaux, F.;
Malloggi, F.; Daillant, J.; Pantoustier, N.; Guenoun, P. &
Perrin, P. (2016), 'Biocompatible Stimuli-Responsive W/O/W
Multiple Emulsions Prepared by One-Step Mixing with a Single
Diblock Copolymer Emulsifier', LANGMUIR 32(42), 10912-10919..
https://dx.doi.org/10.1021/acs.langmuir.6b02590
Multiple emulsions can be also obtained by microfluidics and a
convenient method was demonstrated in :
https://doi.org/10.1039/C7RA05654K
4) Block
copolymers organized on a substrate to form adapted 2D
or 3D nanostructures
How to simply organize nanoscale structures on surfaces ? Block
copolymers offer such a possibility when they are phase separated
(the so-called microphase separation). For instance lamellae or
cylinders with a nanometric lengthscale can be oriented
perpendicular
to a substrate (
Easy
Orientation of Diblock Copolymers on Self-Assembled Monolayers
Using UV Irradiation, Liu PH, Thebault P, Guenoun P, et al.,
MACROMOLECULES Volume: 42 Issue:
24 Pages: 9609-9612 (2009) http://dx.doi.org/10.1021/ma9021357)
by a simple surface energy control.
When constraints are provided by a mold
which is nanoimprinted on the film,
in-plane organization
of the lamellae is favored as shown by experiment and
calculations (collaboration with Tel-Aviv University, David
Andelman) in
an, X. K.;
Andelman, D.; Orland, H.; Thebault, P.; Liu, P. H.; Guenoun,
P.; Daillant, J.; Landis, S., Organization of Block
Copolymers using NanoImprint Lithography: Comparison of
Theory and Experiments. Macromolecules 2011, 44 (7),
2206-2211.
A perfect long-distance arrangement can be obtained by
nanoimprinting in conditions where the polymer thin film
undergoes nanoflows (Thebault, P.; Niedermayer, S.;
Landis, S.; Chaix, N.; Guenoun, P.; Daillant, J.; Man, X.;
Andelman, D. & Orland, H. (2012), 'Tailoring
Nanostructures Using Copolymer Nanoimprint Lithography',
ADVANCED MATERIALS 24(15), 1952-1955.):https://dx.doi.org/10.1002/adma.201103532
The next challenge is now to learn how to grow 3D thick ordered
structures and transform them into metamaterials (
PhD
thesis of Florian AUBRIT with CRPP, Bordeaux, V. Ponsinet). This
is made possible by including plasmonic nanoparticles in polymer
cylinders which are organized perpendicular to a surface.
http://dx.doi.org/10.1039/C8TC01477A
Selected recent publications:
A.
Montiel, T. Nguyen, C.L. Rountree, V. Geertsen, P. Guenoun, D.
Bonamy,
Effect of architecture disorder on the elastic response of
two-dimensional lattice materials,
Phys. Rev. E. 106 (2022).
https://doi.org/10.1103/PhysRevE.106.015004.
N.
Bodin-Thomazo, F. Malloggi, N. Pantoustier, P. Perrin, P.
Guenoun, V. Rosilio,
Formation and stabilization of multiple w/o/w
emulsions encapsulating catechin, by mechanical and microfluidic
methods using a single pH-sensitive copolymer: Effect of
copolymer/drug interaction,
Int. J. Pharm. 622 (2022).
https://doi.org/10.1016/j.ijpharm.2022.121871.
M. Caillaud, F. Gobeaux, M. Hémadi, S.
Boutary, P. Guenoun, D. Desmaële, P. Couvreur, F. Wien, F.
Testard, L. Massaad-Massade,
Supramolecular organization and biological
interaction of squalenoyl siRNA nanoparticles,
Int. J. Pharm. 609 (2021).
https://doi.org/10.1016/j.ijpharm.2021.121117.
M.
Protat, N. Bodin-Thomazo, F. Gobeaux, F. Malloggi, J. Daillant,
N. Pantoustier, P. Perrin, P. Guenoun,
pH and ionic strength triggered destabilization of biocompatible
stable water-in-oil-in-water (W/O/W) emulsions,
JCIS Open. 5 (2022).
https://doi.org/10.1016/j.jciso.2021.100039.
A. Baruch-Leshem, C.
Chevallard, F. Gobeaux, P. Guenoun, J. Daillant, P. Fontaine, M.
Goldmann, A. Kushmaro, H. Rapaport,
Catalytically active peptides affected by self-assembly and
residues order,
Colloids Surfaces B Biointerfaces. 203 (2021).
https://doi.org/10.1016/j.colsurfb.2021.111751.
Manzanarez, H.; Mericq, J. P.;
Guenoun, P. & Bouyer, D.
Modeling the interplay between solvent evaporation and phase
separation
dynamics during membrane
JOURNAL OF MEMBRANE SCIENCE, {2021}, {620}
Gosse, C.; Stanescu, S.; Frederick, J.; Lefrancois, S.;
Vecchiola, A.; Moskura, M.; Swaraj, S.; Belkhou, R.; Watts, B.;
Haltebourg, P.; Blot, C.; Daillant, J.; Guenoun, P. &
Chevallard, C.
A pressure-actuated flow cell for soft X-ray spectromicroscopy
in liquid
media
LAB ON A CHIP, {2020}, {20}, {3213-3229}
Gobeaux, F.; Bizeau, J.; Samson, F.; Marichal, L.; Grillo, I.;
Wien, F.; Yesylevsky, S. O.; Ramseyer, C.; Rouquette, M.;
Lepetre-Mouelhi, S.; Desmaele, D.; Couvreur, P.; Guenoun, P.;
Renault, J.-P. & Testard, F.
Albumin-driven disassembly of lipidic nanoparticles: the
specific case of the squalene-adenosine nanodrug
NANOSCALE, {2020}, {12}, {2793-2809}
Protat, M.; Bodin-Thomazo, N.; Malloggi, F.; Daillant, J.;
Campbell, R. A.; Fragneto, G.; Watkins, E. B.; Perrin, P.;
Pantoustier, N. & Guenoun, P.
Neutron reflectivity measurements at the oil/water interface for
the
study of stimuli-responsive emulsions
EUROPEAN PHYSICAL JOURNAL E, {2018}, {41}
Aubrit, F.; Testard, F.; Paquirissamy, A.; Gobeaux, F.; Wang,
X.; Nallet, F.; Fontaine, P.; Ponsinet, V. & Guenoun, P.
Ligand-free synthesis of gold nanoparticles incorporated within
cylindrical block copolymer films
JOURNAL OF MATERIALS CHEMISTRY C, {2018},
{6}, {8194-8204}
Mastropietro, F.; Godard, P.; Burghammer, M.; Chevallard, C.;
Daillant, J.; Duboisset, J.; Allain, M.; Guenoun, P.; Nouet, J.
& Chamard, V.
Revealing crystalline domains in a mollusc shell
single-crystalline prism
(2017) NATURE MATERIALS, , {16}, {946+}
Bouyer, D.; M'Barki, O.; Pochat-Bohatier, C.; Faur, C.; Petit,
E. & Guenoun, P.
Modeling the membrane formation of novel PVA membranes for
predicting
the composition path and their final morphology
AICHE JOURNAL, {2017}, {63}, {3035-3047}
Brossard, R.; Luchnikov, V.; Guenoun, P. & Malloggi, F.
Patterning of Spontaneous Rolling Thin Polymer Films for
Versatile
Microcapillaries
JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS, {2017},
{55}, {721-728}
Hanafia, A.; Faur, C.; Deratani, A.; Guenoun, P.; Garate, H.;
Quemener, D.; Pochat-Bohatier, C. & Bouyer, D.
Fabrication of novel porous membrane from biobased water-soluble
polymer
(hydroxypropylcellulose)
JOURNAL OF MEMBRANE SCIENCE, {2017}, {526},
{212-220}
Protat, M.; Bodin, N.; Gobeaux, F.; Malloggi, F.; Daillant, J.;
Pantoustier, N.; Guenoun, P. & Perrin, P.
Biocompatible Stimuli-Responsive W/O/W Multiple Emulsions
Prepared by
One-Step Mixing with a Single Diblock Copolymer Emulsifier
LANGMUIR, {2016}, {32}, {10912-10919}
Chevalier, N. R. & Guenoun, P.
Surface Tension Drives the Orientation of Crystals at the
Air-WaterbnInterface
JOURNAL OF PHYSICAL CHEMISTRY LETTERS, {2016},
{7}, {2809-2813}
Sarrazin, B.; Tsapis, N.; Mousnier, L.; Taulier, N.; Urbach, W.
& Guenoun, P.
AFM Investigation of Liquid-Filled Polymer Microcapsules
Elasticity
LANGMUIR, {2016}, {32},
{4610-4618}
Sarrazin, B.; Brossard, R.; Guenoun, P. & Malloggi, F.
Investigation of PDMS based bi-layer elasticity via
interpretation of apparent Young's modulus
SOFT MATTER, {2016}, {12}, {2200-2207}
Besnard, L.; Protat, M.; Malloggi, F.; Daillant, J.; Cousin, F.;
Pantoustier, N.; Guenoun, P. & Perrin, P.
Breaking of the Bancroft rule for multiple
emulsions stabilized by a single stimulable polymer
SOFT MATTER, {2014}, {10}, {7073-7087}
Tseng, Y.-H.; Chevallard, C.; Dauphin, Y. &
Guenoun, P.
CaCO3 nanostructured crystals induced by nacreous organic
extracts
CRYSTENGCOMM, {2014}, {16}, {561-569}
M'barki, O.; Hanafia, A.; Bouyer, D.; Faur, C.;
Sescousse, R.; Delabre, U.; Blot, C.; Guenoun, P.; Deratani,
A.; Quemener, D. & Pochat-Bohatier, C.
Greener method to prepare porous polymer membranes by
combining thermally induced phase separation and crosslinking
of poly (vinylalcohol) in water
JOURNAL OF MEMBRANE SCIENCE, {2014}, {458},
{225-235}
Salva, R.; Le Meins, J.-F.; Sandre, O.; Brulet, A.;
Schmutz, M.; Guenoun, P. & Lecommandoux, S.
Polymersome Shape Transformation at the Nanoscale
ACS NANO, {2013}, {7}, {9298-9311}
Besnard, L.; Marchal, F.; Paredes, J. F.; Daillant, J.;
Pantoustier, N.; Perrin, P. & Guenoun, P. Multiple
Emulsions Controlled by Stimuli-Responsive Polymers
ADVANCED MATERIALS, {2013}, {25},
{2844-2848}
Nuss, H.; Chevallard, C.; Guenoun, P. & Malloggi, F.
(2012), 'Microfluidic trap-and-release system for
lab-on-a-chip-based studies on giant vesicles', LAB ON A CHIP
12(24), 5257-5261.
Chevalier, N. R.; Chevallard, C.; Goldmann, M.;
Brezesinski, G. & Guenoun, P. (2012), 'CaCO3
Mineralization under beta-Sheet Forming Peptide Monolayers',
CRYSTAL GROWTH & DESIGN 12(5), 2299-2305.
Thebault, P.; Niedermayer, S.; Landis, S.; Chaix, N.;
Guenoun, P.; Daillant, J.; Man, X.; Andelman, D. & Orland,
H. (2012), 'Tailoring Nanostructures Using Copolymer
Nanoimprint Lithography', ADVANCED MATERIALS 24(15),
1952-1955.
Publications