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Univ. Paris-Saclay
Low-energy photoionization of guanine quadruplexes
Mercredi 08/09/2021, 14:00-17:01
Amphi. Bloch, Bât. 774, Orme des Merisiers, CEA-Saclay

The thesis deals with the photoionization of guanine quadruplexes, which are four-stranded DNA structures playing a key role in many biological functions. Their propensity to eject an electron upon absorption of a single photon with energy lower than the ionization potential of their components is significantly greater compared to that of single and double strands. Nanosecond transient absorption spectroscopy was used to quantify the generated transient species, ejected electrons and guanine radicals, and follow the reaction dynamics. These species are precursors to DNA damage and their characterization is essential for the development of photoconductivity-based biosensors.

Contact : Caroline LEBE


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