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Ultrafast Nanophotonics Group



Laboratoire Interactions, Dynamiques et Lasers


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PhD thesis: French-Russian joint international supervision

Title   :

Spatio-temporal modeling of laser-tissue interaction in multimodal spectroscopy for cancer and pre-cancer states of epithelial tissue in vivo [IJ1, IJ2] [IC1, IC2, IC3, IC4, IC5, IC6] [NC1, NC2, NC3, NC4]

Laboratory (France)  :

Université de Lorraine (UL) (Nancy, France)
Centre de Recherche en Automatique de Nancy (CRAN), UMR 7039, Centre National de la Recherche Scientifique (CNRS) & UL

Supervisor  :

Prof. Walter BLONDEL

Co-supervisor  :

Prof. Christian DAUL 

Laboratory (Russia) :

Laser Biospectroscopy Lab., Natural Sciences Center, A.M. Prokhorov General Physics Institute, Russian Academy of Sciences (Moscow, Russia)

Supervisor : 

Prof. Victor B. LOSCHENOV

Description :

Modeling of plasmon nanoparticles optical properties, experimental and theoretical modeling of light-tissue interactions in multilayered  tissue, inverse problem solution based on forward Monte Carlo problem, experimental and theoretical life-time modeling of fluorophores in present of nanoparticles 

Financial support :

Conseil Régional de Lorraine
French Embassy in Moscow

Master thesis

Title :  

Research on laser and laser-induced fluorescence interaction  with model of nervous tissue and nervous tissue in vitro  [IC7, IC8] [NC5, NC6]


Laser Biospectroscopy  Lab., Natural Sciences Center,  General Physics Institute, Russian Academy of Sciences, Russia, Moscow


Prof. LOSCHENOV Victor B.

Short abstract

Research on laser-induced fluorescence and diffused light interaction with nervous tissue and with models of nervous tissue, estimation of effective laser-induced fluorescence anisotropy factor, Monte Carlo modeling and diffusion approximation



PhD, Université de Lorraine, Nancy, France; CRAN-CNRS-UL - École Doctorale IAEM Lorraine (ED 77) Computer science, Automatic control, Electronics and Mathematics .


PhD, Laser Biospectroscopy  Lab., GPI RAS, Moscow, Russia, Laser physics.


Physicist, Moscow Engineering Physics Institute (MEPhI), Faculty of Theoretical and Experimental Physics, Moscow, Russia, Medical Physics Specialist.


High school, Gymnasium 1579, Moscow, Russia.




Post-doctorate  researcher, CEA Saclay - Lasers, Dynamics,  Interactions  Lab., Gif-sur-Yvette, France,VOXEL project - Volumetric medical X-ray imaging at extremely low dose, Nanoimagin project - Interface, methods and setup development for 3D/4D diffrac- tion imaging of biological objects.

0  Manager of Nanoimagin project:

- responsible for 2 PhD students and 2 trainees;

- modified a setup for diffraction imaging and holography in optical region of wave-lengths in order to achieve higher resolution and adapt the setup for biological objects, which are considered to be diffuse and alter the diffraction pattern;

- simulated in FDTD a single nanostructured high harmonics generation media in order to confine the optical field at certain wavelengths and obtain high numerical aperture for diffraction imaging setup and get higher lateral and axial resolution.

- 2 patents in process:

· apparatus for 3D/4D diffraction imaging of diffuse biological objects in vivo;

· tapered nanofibers fabrication method and application to imaging systems of live objects;

0  Member of VOXEL project:

- developped an algorithm allowing for sorting sparse images obtained from X-radiffraction measurements and as a results receive a data with sufficient signal to noise ratio allowing for following reconstruction of a 3D object;

- co-author of 1 article in process: 3D stereo single acquisition imaging using highg harmonics generation.


Engineer,  Laser Biospectroscopy Lab., Natural Sciences Center,  General Physics Institute, Russia Academy of Sciences, Moscow, Russia, Detailed achievements in several multidisciplinary  projects and clinical research.

0  Gynecology [NJ1, NJ2, NJ3] [NC7]:

- method of 4 steps photodynamic therapy of several types of vulvovaginal candidiasis was elaborated under control of fluorescent diagnosis, laser radiation - 405 nm;

- photodynamic effect achieved on 40 patients, no recurrences during 4 years;

- statistical analysis of spectroscopic data;

- spectroscopic assistance.

0  Neurosurgery [IC9, IC10, IC11] [NJ4, NJ5] [NC8, NC9, NC10] [P1, P2] [M1]:

- preliminary experiments on phantoms;

- combined analysis: oxygenation measurements, fluorescent spectroscopy and visual-ization of pathological  changes during surgeries;

- the spectroscopic measurements assistance during neurosurgeries;

- statistical analysis of spectroscopic data;

- 2 patents [P1, P2].

0  Proctology [IC12] [NC11]:

- coagulation method of blood nodes approved on models [NC12]  and on real tissue during the surgeries

  - 1 patent [P3];

0  Optical fibers investigation for fluorescent diagnosis for resolved probing of tissues in depth.


Russian Native

English Upper-Intermediate                                                              

  • School (10 years) University (2 years) Scientific
  • TOEIC (840/990)

French  B2                                                 

  • Courses in CAFOL, Nancy, France (5 months) C
  • ourses in Russian Academy of Sciences (4 months)
  • Ph.D. (3x6 months), living in France since 2016
  • Private lessons (5 months)

German Basics                                                                               

  • School (10 years)

Computer skills


  • Interfaces, VI’s for new equipment


  • Inverse problem solving, Interfaces, Modeling of light-tissue interactions Signal and Image processing


  • Signal and Image processing

Wolfram Mathematics                         

  • Modeling of nanoparticles optical properties

 COMSOL Multiphysics                                                                       

  • RF module


  • FDTD module


  • Writing articles, making presentations


  • Scientific purposes

 Microsoft Office                                                                       

  • Scientific purposes


Prof. Hamed MERDJI   CEA Saclay//DRF//IRAMIS//LIDyL//Ultrafast Nanophotonics group, Gif-Sur-Yvette, France

Prof. Walter BLONDEL   CRAN, Universite de Lorraine, Nancy, France - UMR 7039 CNRS, Nancy, France

Prof. VictoLOSCHENO Laser Biospectroscopy  Lab., GPI RAS, Moscow, Russian - MEPhI, Moscow, Russia

Prof. Christian DAUL   CRAN, Universite de Lorraine, Nancy, France - UMR 7039 CNRS, Nancy, France

Prof. Sergey GONCHUKO

Courses followed during PhD studies

Denis Maillet   Inverse problems solution: methods and models                                        21 h

Alain Hazotte  Image Processing and Quantitative  Microscopy                                         24 h

Denis Roegel  LATEXfor scientific purposes                                                                               20 h

CAFOL, Nancy, France  French  as a foreign language                                                          2 x 48 h


Science  Connections between different areas in science, news and developments

Self-development   There are no limits

Reading Classical literature, history, architecture

Teaching  Physics and mathematics

Sport  Surfing, snowboarding, mountain skiing, yachting, windsurfing, wakeboarding, ice- and roller-skating, cycling, longboarding.

#147 - Mise à jour : 05/09/2018

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