The project is dedicated to the study of new approach of microscopy based on development of miniaturized visible-light microscopy by removing the optical aberration. Avoiding to use imaging optics is a perfect solution for biomedical investigation due to its portability and in-vivo analysis providing much more compact, cost-effective and wider FOV imagers. Obtaining such an image in a single shot greatly reduces acquisition and calculation times, allowing real-time filming of biological processes, for example.

This device, called NANOXIM, consists of a laser diode and a CCD camera, between which the sample is placed. The apparent simplicity of the NanoXim goes hand in hand with its ability to change configuration - experimental and algorithmic - depending on the nature of the observed object: it is no longer the sample to adapt to the experience, but the reverse. Reconstructions are usually performed after detection. The assembly then forms a complete and versatile imaging system capable of observing 3D samples.