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Univ. Paris-Saclay

Sujet de stage / Master 2 Internship

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Study of dielectric and hybrid particles for the implementation of nanolabels for bioimaging

Contact: FIORINI Celine, , celine.fiorini@cea.fr, +33 1 69 08 62 38/19 76
The internship aims at analyzing the frequency conversion properties (2nd harmonic generation - SHG) of nanometric dielectric particles in view of their future implementation for labeling and imaging in biology : the objective will more particularly be to demonstrate the possibility of enhancing the SHG signal of these particles following their coupling to a plasmonic nanoantennae. This work will be carried out in a collaborative framework, an already functional characterization set-up coupling optical and topographic measurements of individual nano-objects, will be taken into profit.
Possibility of continuation in PhD: Oui
Deadline for application:01/03/2021

Full description:
Following a previous work carried out within the framework of a collaboration between our laboratory and 2 other laboratories of the Plateau de Saclay (ENS Paris-Saclay/ LUMIN and CentraleSupelec/ MSMAT), we were able to highlight the interest of doped BaTiO3 dielectric nanoparticles for optical bioimaging. More particularly, the properties of both luminescence and frequency conversion (second harmonic generation - SHG) of these particles make them particularly interesting as labels for the analysis of intracellular transport within neural networks, opening the way to the study of disorders induced by neuropsychiatric or neurodegenerative diseases.

The objective of the internship will be to analyze the optical properties of particles of reduced size (< 100 nm) using a home-built characterization set-up coupling an atomic force microscope (AFM) to an optical microscope associated with various laser excitations: the aim will more particularly be to evidence the possibility of enhancing the SHG signal of these particles following their coupling to plasmonic nanoantennas. Various types of plasmonic antennas have been considered and simulations are currently in progress. Depending on the results, different hybrid objects associating BaTiO3 particles to gold particles or gold coatings will be synthesized by our collaborators (CEA, CentraleSupelec or Institut Langevin).
The host team is the Nanophotonics group of SPEC/LEPO (http://iramis.cea.fr/spec/LEPO/). For the needs of its research, the group has developed an important know-how in the coupling of optical measurements with local probe microscopies. The team has several experimental benches of this type, operating in air or under ultra-high vacuum: optics and nonlinear optics of nano-objects, new methods of optical microscopy with active probe ...

The role of the student will range from sample preparation (in partnership with the project collaborators), to the characterization of their frequency conversion properties (spectral and polarization-resolved analyses). He will also participate in the interpretation of the results that will be obtained.
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