+33 1 69 08 64 82
Researcher in CEA
Developments in the field of hyperpolarization to increase the sensitivity of Nuclear Magnetic Resonance
Cage-molecules in solution binding gases.
Non-linear effects observed by liquid phase NMR. This project called IMAGINE, for "NMR Investigation of MAGnetization-Induced Non-linear Effects" is financed by ANR and FWF.
Metabolic profiling by NMR
|2006||Habilitation to lead research|
|2002 -||Researcher in CEA (IRAMIS / NIMBE / LSDRM)|
|1999 - 2001||Researcher in Metabolix Explorer|
|1998 - 1999||Post-doctoral position in the laboratory BIP-CNRS of Marseille, France, Supervisor Dr. Françoise Guerlesquin|
|1996 - 1998||Post-doctoral position in the laboratory of NMR, university of Florence, Italy, Supervisor Pr. Ivano Bertini|
|1993 - 1996||Ph-D thesis in the service of Inorganic and Biological Chemistry of CEA, Grenoble, France, Supervisor Dr. Jacques Gaillard|
|1993||Chemical Engineering degree of ESCIL, now CPE, Lyon|
45. Single-scan diffusion-ordered NMR spectroscopy of SABRE-hyperpolarized mixtures
L Guduff, P Berthault, C van Heijenoort, J-N Dumez, G Huber, ChemPhysChem, 2019, 20, 392-398.
44. HR-μMAS NMR-based metabolomics: localized metabolic proﬁling of a garlic clove with μg tissues
C Lucas-Torres, G Huber, A Ichikawa, Y Nishiyama, A Wong, .
43. Functionalization of Bambusurils by thiol-ene click reaction and new, facile method for the preparation of anion-free Bambusurils
D Azazna, M Lafosse, J. Rivollier, J Wang, I Ben Cheikh, M Meyer, P Thuéry, J-P Dognon, G, Huber, M-P Heck, .
42. Unsaturated cryptophanes: toward dual PHIP/hyperpolarised xenon sensors
G Huber, E Léonce, O Baydoun, N De Rycke, T Brotin, P Berthault,
41. Metabolomic and proteomic investigations of impacts of titanium dioxide nanoparticles on Escherichia coli
M Planchon, T Léger, O Spalla, G Huber, R Ferrari, .
40. Single-scan multidimensional NMR analysis of mixtures at sub-millimolar concentrations using SABRE hyperpolarization
V Daniele, F-X Legrand, P Berthault, J-N Dumez, G Huber, .
39. Nuclear spin noise in NMR revisited,
G Ferrand, G Huber, M Luong, H Desvaux, .
38. A more accurate tuning-matching technique for NMR probes using wobulation and variable phase shifter,
G Ferrand, M Luong, G Huber, H Desvaux, .
37. On the tuning of high resolution NMR probes,
M T Pöschko, J Schlagnitweit, G Huber, M Nausner, M Horničáková, H Desvaux, N Müller, .
36. Synthesis of cucurbituril derivatives and insights into their solubility in water,
V Lewin, J Rivollier, S Coudert, A Buisson, D Baumann, B Rousseau, F-X Legrand, H Kourilová, P Berthault, J-P Dognon, M-P Heck, G Huber, .
35. Multiple echoes due to distant dipolar fields in NMR of hyperpolarized noble gas solutions,
S W Morgan, E Baudin, G Huber, P Berthault, G Tastevin, M Goldman, P-J Nacher, and H Desvaux, .
34. Cell uptake of a biosensor detected by hyperpolarized 129Xe NMR: The transferrin case,
C Boutin, A Stopin, F Lenda, T Brotin, J-P Dutasta, N Jamin, A Sanson, Y Boulard, F Leteurtre, G Huber, A Bogaert-Buchmann, N Tassali, H Desvaux, M Carrière, and P Berthault, .
33. Interaction of Xenon with Cucurbituril in Water,
G Huber, F-X Legrand, V Lewin, D Baumann, M-P Heck, P Berthault, .
32. A water-soluble Xe@cryptophane-111 complex exhibits very high thermodynamic stability and a peculiar 129Xe NMR chemical shift, RM Fairchild, AI Joseph, KT Holman, HA Fogarty, T Brotin, J-P Dutasta, C Boutin, G Huber, P Berthault, .
31. Biosensing using laser-polarized xenon NMR/MRI,
P Berthault, G Huber, H Desvaux, .
30. Nuclear spin-noise spectra of hyperpolarized systems,
H Desvaux, D J-Y Marion, G Huber, P Berthault, .
29. Towards thrombosis-targeted zeolite nanoparticles for laser-polarized 129 Xe MRI,
F Lerouge, O Melnyk, J-O Durand, L Raehm, P Berthault, G Huber, H Desvaux, A Constantinesco, P Choquet, J Detour, M Smaïhi, .
28. Sensitivity and multiplexing capabilities of MRI based on hyperpolarized 129Xe biosensors,
P Berthault, A Bogaert, H Desvaux, G Huber, Y Boulard, .
27. Cryptophane-xenon complexes in organic solvents observed through NMR spectroscopy,
G Huber, L Beguin, H Desvaux, T Brotin, H A Fogarty, J-P Dutasta, P Berthault, .
26. Observation of noise-triggered chaotic emissions in an NMR-maser,
D J-Y Marion, G Huber, P Berthault, H Desvaux, .
25. Effects on 1 H and 129 Xe NMR spectra of large magnetization created by dissolved laser-polarized xenon,
D J-Y Marion, G Huber, P Berthault, H Desvaux, .
24. A cryptophane core optimized for xenon encapsulation,
H A Fogarty, P Berthault, T Brotin, G Huber, H Desvaux, J-P Dutasta, .
23. A cryptophane biosensor for detection of specific nucleotide targets through xenon-NMR,
V Roy, T Brotin, J-P Dutasta, M-H Charles, T Delair, F Mallet, G Huber, H Desvaux, Y Boulard, P Berthault, .
22. 1H and 129 Xe NMR absorption line shapes in the presence of highly polarized and concentrated xenon solutions in high magnetic field,
D J Marion, G Huber, L Dubois, P Berthault, H Desvaux, .
21. Direct enhancement of any solution NMR signal using the distant dipolar fields created by highly polarized and concentrated nuclear spin systems,
H Desvaux, D J Marion, G Huber, L Dubois, P Berthault, .
20. Water soluble cryptophanes showing unprecedented affinity for xenon: candidates as NMR-based biosensors,
G Huber, T Brotin, L Dubois, H Desvaux, J-P Dutasta, P Berthault, .
19. Study of the hydrophobic cavity of β-cryptogein through laser-polarized xenon NMR spectroscopy,
P Berthault, G Huber, P T Ha, L Dubois, H Desvaux, E Guittet, .
18. Dynamics of xenon binding inside the hydrophobic cavity of pseudo wild-type bacteriophage T4 lysozyme explored through xenon-based NMR spectroscopy,
H Desvaux, L Dubois, G Huber, M L Quillin, P Berthault, M W Matthews, .
17. Regioselective one-step synthesis of hexahydroxy permethylated β-cyclodextrin and unambiguous NMR analysis,
Y Chen, JG Huber, Zhang Y et Sinaÿ P, .
16. Probing hydrophobic cavities of lipid transfer protein from Nicotiana tabacum though Xenon-based NMR,
L Dubois, Da Silva P, Landon C, JG Huber, Ponchet M, Vovelle F, P Berthault, H Desvaux, .
15. NMR study of optically active monosubstituted cryptophanes and their interaction with xenon,
JG Huber, L Dubois, H Desvaux, T BrotinT, J-P Dutasta, P Berthault, .
14. Diisobutylaluminum hydride as a molecular scalpel: the regioselective stripping of four methyl groups from permethylated b-cyclodextrin,
X Luo, Y Chen, JG Huber, Y Zhang, P Sinaÿ, .
13. Mapping hydrophobic molecular regions using dissolved laser-polarized xenon NMR,
L Dubois, P Berthault, JG Huber, H Desvaux, .
12. Dynamics of xenon inside cavities as probed by NMR relaxation of dissolved laser-polarized xenon,
L Dubois, S Parrès, JG Huber, P Berthault, H Desvaux, .
11. Magnetization transfer from laser-polarized xenon to protons with spin-diffusion quenching,
H Desvaux, JG Huber, T Brotin, J-P Dutasta, P Berthault, .
10. Protein-hydration and location of water molecules in oxidized horse heart cytochrome c by (1)H NMR,
I Bertini, JG Huber, C Luchinat, M Piccioli, .
9. Solution structure of reduced horse heart cytochrome c,
L Banci, I Bertini, JG Huber, GA Spyroulias, P Turano, .
8. Unusual NMR, EPR, and Mossbauer properties of Chromatium vinosum ,
P Kyritsis, R Kümmerle, JG Huber, J Gaillard, B Guigliarelli, C Popescu, E Münck, J-M Moulis, .
7. Partial orientation of oxidized and reduced cytochrome b 5 at high magnetic fields : magnetic susceptibility anisotropy contributions and consequences for protein solution structure determination,
L Banci, I Bertini, JG Huber, C Luchinat, A Rosato, .
6. ePHOGSY experiments on a paramagnetic protein : location of the catalytic water molecule in the heme crevice of the oxidized form of horse heart cytochrome c.
I Bertini, C Dalvit, JG Huber, C Luchinat, M Piccioli, .
5. Intramolecular electron transfer between [4Fe-4S] clusters studied by PMR spectroscopy,
P Kyritsis, JG Huber, I Quinkal, J Gaillard, J-M Moulis, .
4. Use of 1 H longitudinal relaxation times in the solution structure of paramagnetic proteins. Applications to [4Fe-4S] proteins.
JG Huber, J-M Moulis, J Gaillard, .
3. The GC-MS analysis of organic intermediates from the TiO2 photocatalytic treatment of water contaminated by lindane (1a, 2a, 3b, 4a, 5a, 6b-hexachlorocyclohexane),
C Guillard, P Pichat, G Huber, C Hoang-Van, J. of Adv. Oxidation technologies, 1996, 1, 53-60.
2. NMR of Chromatium vinosum ferredoxin : evidence for structural inequivalence and impeded electron transfer between the two [4Fe-4S] clusters.
JG Huber, J Gaillard, J-M Moulis, Biochemistry, 1995, 34, 194-205.
1. Use of the TiO2-UV system to detoxify water contaminated by lindane (1α, 2α, 3ß, 4α, 5α, 6ß-Hexachlorocyclohexane),
C Guillard, G Huber, P Pichat, C Hoang-Van, Soil & Environment 1995, 5, 1233.
4. Cucurbituril derivatives as oxygen carriers,
B Prieur, M-P Heck, G Huber, owner B Prieur, 2017. EP17305480
3. Characterization of rubbers and rubber derivatives by NMR,
JG Huber, B Gonzalez, L d'Auriol, owner Metabolic Explorer, 2001. WO02068946-A,1.
2. Coupling device between a reactor and a NMR spectrometer,
B Gonzalez, JG Huber, L d'Auriol, owners Metabolic Explorer, Bruker SA, 2000. .
1. Method and apparatus for analyzing the chemical state of living cells by nuclear magnetic resonance,
B Gonzalez, JG Huber, M Piotto, M Renaud, owners Université d'Auvergne, BRUKER SA, 2000. .