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Gaspard HUBER


NIMBE, nanosciences et Innovation

LSDRM, Laboratory 'Structure and Dynamics by Magnetic Resonance'

fr Version française

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Researcher in CEA

Thema of research

Developments in the field of hyperpolarization to increase the sensitivity of Nuclear Magnetic Resonance


2006 Habilitation to lead research
2002 - Researcher in CEA (IRAMIS / NIMBE / LSDRM)
1999 - 2001 Researcher in Metabolix Explorer
1998 - 1999 Post-doctoral position in the laboratory BIP-CNRS of Marseille, France, Supervisor Dr. Françoise Guerlesquin
1996 - 1998 Post-doctoral position in the laboratory of NMR, university of Florence, Italy, Supervisor Pr. Ivano Bertini
1996 Ph-D thesis
1993 - 1996 Ph-D thesis in the service of Inorganic and Biological Chemistry of CEA, Grenoble, France, Supervisor Dr. Jacques Gaillard
1993 Chemical Engineering degree of ESCIL, now CPE, Lyon

Scientific publications

  1. Single-scan multidimensional NMR analysis of mixtures at sub-millimolar concentrations using SABRE hyperpolarization
    V. Daniele, F.-X. Legrand, P. Berthault, J.-N. Dumez, G.Huber, ChemPhysChem, 2015, 16, 3413-3417.
  2. Nuclear spin noise in NMR revisited,
    G. Ferrand, G. Huber, M.Luong, H. Desvaux, J. Chem. Phys., 2015, 143, 094201.
  3. A more accurate tuning-matching technique for NMR probes using wobulation and variable phase shifter,
    G. Ferrand, M. Luong, G. Huber, H. Desvaux, Conc. Magn. Reson., 2015, 45B, 59.
  4. On the tuning of high resolution NMR probes,
    M. T. Pöschko, J. Schlagnitweit, G. Huber, M. Nausner, M. Horničáková, H. Desvaux, N. Müller, ChemPhysChem, 2014, 15, 3639.
  5. Synthesis of cucurbit[6]uril derivatives and insights into their solubility in water,
    V. Lewin, J. Rivollier, S. Coudert, D. Alexandre Buisson, D. Baumann, B. Rousseau, F.-X. Legrand, H. Kourilová, P. Berthault, J.-P. Dognon, M.-P.Heck, G.Huber, Eur. J. Org. Chem., 2013, 3857.
  6. Multiple echoes due to distant dipolar fields in NMR of hyperpolarized noble gas solutions,
    S. W. Morgan, E. Baudin, G. Huber, P. Berthault, G. Tastevin, M. Goldman, P.-J. Nacher, and H. Desvaux, Eur. Phys. J. D., 2013, 67, 29.
  7. Cell uptake of a biosensor detected by hyperpolarized 129Xe NMR: The transferrin case,
    C. Boutin, A. Stopin, F. Lenda, T. Brotin, J.-P. Dutasta, N. Jamin, A. Sanson, Y. Boulard, F. Leteurtre, G. Huber, A. Bogaert-Buchmann, N. Tassali, H. Desvaux, M. Carrière, and P. Berthault,  Bioorg. Med. Chem., 2011, 19, 4135-4143.
  8. Interaction of Xenon with Cucurbit[5]uril in Water, 
    G. Huber, F.-X. Legrand, V. Lewin, D. Baumann, M.-P. Heck, P. Berthault, ChemPhysChem, 2011, 1053-1055.
  9. A water-soluble Xe@cryptophane-111 complex exhibits very high thermodynamic stability and a peculiar 129Xe NMR chemical shift, 
    Fairchild RM, Joseph AI, Holman KT, Fogarty HA, Brotin T, Dutasta J-P, Boutin C, Huber G, Berthault P, J. Am. Chem. Soc., 2010, 132, 15505-15507.
  10. Biosensing using laser-polarized xenon NMR/MRI, 
    Berthault P, Huber G, Desvaux H, Prog. NMR Spectrosc., 2009, 55, 35-60 .
  11. Nuclear spin-noise spectra of hyperpolarized systems,
    Desvaux H, Marion D J, Huber G, Berthault P,  Angew. Chem. Int. Ed. 2009, 48, 4341-4343.
  12. Sensitivity and multiplexing capabilities of MRI based on hyperpolarized 129Xe biosensors, 
    Berthault P, Bogaert A, Desvaux H, Huber G, Boulard Y, J. Am. Chem. Soc., 2009, 130, 16456-16457.
  13. Towards thrombosis-targeted zeolite nanoparticles for laser-polarized 129 Xe MRI, 
    Lerouge F, Melnyk O, Durand, J-O, Raehm, L, Berthault P, Huber G, Desvaux H, Constantinesco A, Choquet P, Detour J, Smaïhi M, J. Mater. Chem, 2009, 19, 379-386.
  14. Cryptophane-xenon complexes in organic solvents observed through NMR spectroscopy, 
    Huber G, Beguin L, Desvaux H, Brotin T, Fogarty H A, Dutasta J-P, Berthault P, J. Phys. Chem. A, 2008, 112, 11363-11372.
  15. Observation of noise-triggered chaotic emissions in an NMR-maser,
    Marion D J-Y, Huber G, Berthault P, Desvaux H,  ChemPhysChem, 2008, 9, 1395-1401.
  16. Effects on H and 129 Xe NMR spectra of large magnetization created by dissolved laser-polarized xenon, 
    Marion D J, Huber G, Berthault P, Desvaux H, C. R. Chimie, 2008, 11, 553-559.
  17. A cryptophane core optimized for xenon encapsulation,
    Fogarty H A, Berthault P, Brotin T, Huber G, Desvaux H, Dutasta J-P,  J. Am. Chem. Soc., 2007, 129, 10332-10333.
  18. A cryptophane biosensor for detection of specific nucleotide targets through xenon-NMR, 
    Roy V, Brotin B, Dutasta J-P, Charles M-H, Delair T, Mallet F, Huber G, Desvaux H, Boulard Y, Berthault P, ChemPhysChem, 2007, 8, 2082-2085.
  19. 1H and 129 Xe NMR absorption line shapes in the presence of highly polarized and concentrated xenon solutions in high magnetic field,
    Marion D J, Huber G, Dubois L, Berthault P, Desvaux H,  J. Magn. Reson., 2007, 187, 78-87.
  20. Direct enhancement of any solution NMR signal using the distant dipolar fields created by highly polarized and concentrated nuclear spin systems, 
    Desvaux H, Marion D J, Huber G, Dubois L, Berthault P, Eur. Phys. J. Appl. Phys., 2006, 36, 25–34.
  21. Water soluble cryptophanes showing unprecedented affinity for xenon: candidates as NMR-based biosensors, 
    Huber G, Brotin T, Dubois L, Desvaux H, Dutasta J-P, Berthault P, J. Am. Chem. Soc., 2006, 128, 6239-6246.
  22. Study of the hydrophobic cavity of β-cryptogein through laser-polarized xenon NMR spectroscopy, 
    Berthault P, Huber G, Ha PT, Dubois L, Desvaux H, Guittet E, ChemBioChem, 2006, 7, 59-64.
  23. Dynamics of xenon binding inside the hydrophobic cavity of pseudo wild-type bacteriophage T4 lysozyme explored through xenon-based NMR spectroscopy,
    Desvaux H, Dubois L, Huber G, Quillin ML, Berthault P, Matthews MW,  J. Am. Chem. Soc., 2005, 127, 11676-11683.
  24. Regioselective one-step synthesis of hexahydroxy permethylated β-cyclodextrin and unambiguous NMR analysis, 
    Chen Y, Huber JG, Zhang Y et Sinaÿ P, C.R. Chimie, 2005, 8, 27-30.
  25. Probing hydrophobic cavities of lipid transfer protein from Nicotiana tabacum though Xenon-based NMR, 
    Dubois L, Da Silva P, Landon C, Huber JG, Ponchet M, Vovelle F, Berthault P, Desvaux H, JACS, 2004, 126, 15738-15746.
  26. NMR study of optically active monosubstituted cryptophanes and their interaction with xenon,
    Huber JG, Dubois L, Desvaux H, Brotin, T, Dutasta, JP, Berthault P,  J. Phys. Chem. A, 2004, 108, 9608-9615.
  27. Diisobutylaluminum hydride as a molecular scalpel: the regioselective stripping of four methyl groups from permethylated b-cyclodextrin, 
    Luo X, Chen Y, Huber JG, Zhang Y, Sinaÿ P,  C.R. Chimie, 2004, 7, 25-28.
  28. Mapping hydrophobic molecular regions using dissolved laser-polarized xenon NMR, 
    Dubois L, Berthault P, Huber JG, Desvaux H, C. R. Physique, 2004, 5, 305-313.
  29. Dynamics of xenon inside cavities as probed by NMR relaxation of dissolved laser-polarized xenon,
    Dubois L, Parrès S, Huber JG, Berthault P, Desvaux H,  J Phys Chem B, 2004, 108, 767-773.
  30. Magnetization transfer from laser-polarized xenon to protons with spin-diffusion quenching, 
    Desvaux H, Huber JG, Brotin T, Dutasta J-P, Berthault P,  Chem Phys Chem, 2003, 4, 384-387.
  31. Protein-hydration and location of water molecules in oxidized horse heart cytochrome c by (1)H NMR,
    Bertini I, Huber JG, Luchinat C, Piccioli M,  J Magn Reson, 2000, 147, 1-8.
  32. Solution structure of reduced horse heart cytochrome c, 
    Banci L, Bertini I, Huber JG, Spyroulias GA, Turano P, J. Biol. Inorg. Chem., 1999, 4, 21-31.
  33. Unusual NMR, EPR, and Mossbauer properties of Chromatium vinosum 
    Kyritsis P, Kümmerle R, Huber JG, Gaillard J, Guigliarelli B, Popescu C, Münck E, Moulis J-M, Biochemistry, 1999, 38, 6335-6345.
  34. Partial orientation of oxidized and reduced cytochrome b at high magnetic fields : magnetic susceptibility anisotropy contributions and consequences for protein solution structure determination,
    Banci L, Bertini I, Huber JG, Luchinat C, Rosato A,  J. Am. Chem. Soc., 1998, 120, 12903-12909.
  35. ePHOGSY experiments on a paramagnetic protein : location of the catalytic water molecule in the heme crevice of the oxidized form of horse heart cytochrome c. 
    Bertini I, Dalvit C, Huber JG, Luchinat C, Piccioli M, FEBS letters, 1997, 415, 45-48.
  36. Intramolecular electron transfer between [4Fe-4S] clusters studied by PMR spectroscopy, 
    Kyritsis P, Huber JG, Quinkal I, Gaillard J, Moulis J-M, Biochemistry, 1997, 36, 7839-7846.
  37. Use of H longitudinal relaxation times in the solution structure of paramagnetic proteins. Applications to [4Fe-4S] proteins. 
    Huber JG, Moulis J-M, Gaillard J, Biochemistry, 1996, 35, 12705-12711.
  38. The GC-MS analysis of organic intermediates from the TiOphotocatalytic treatment of water contaminated by lindane (1a, 2a, 3b, 4a, 5a, 6b-hexachlorocyclohexane),
    Guillard C, Pichat P, Huber G, Hoang-Van C, J. of Adv. Oxidation technologies, 1996, 1, 53-60.
  39. NMR of Chromatium vinosum ferredoxin : evidence for structural inequivalence and impeded electron transfer between the two [4Fe-4S] clusters.
    Huber JG, Gaillard J, Moulis J-M, Biochemistry, 1995, 34, 194-205.
  40. Use of the TiO2-UV system to detoxify water contaminated by lindane (1α, 2α, 3ß, 4α, 5α, 6ß-Hexachlorocyclohexane),
    Guillard C, Huber G, Pichat P et Hoang-Van C, Soil & Environment 1995, 5, 1233.


  1. Caractérisation de caoutchoucs et dérivés de caoutchoucs par RMN,
    Huber JG, Gonzalez B, d'Auriol L, propriétaire Metabolic Explorer, 2001. Brevets n° FR2821430 WO02068946-A,1.
  2. Dispositif de couplage entre un réacteur et un appareil d'analyse spectroscopique par RMN,
    Gonzalez B, Huber JG, d'Auriol L, propriétaires Metabolic Explorer, Bruker SA,  2000. Brevets n° FR2816713, EP 1342097, WO/2002/041021.
  3. Procédé et dispositif pour analyser l'état chimique de cellules vivantes par résonance magnétique nucléaire,
    Gonzalez B, Huber JG, Piotto M, Renaud M, propriétaires Université d'Auvergne, BRUKER SA,  2000. Brevets n° FR2815357, EP1410055, US20030199751, WO/2002/031523.


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