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PhD subjects

5 sujets IRAMIS

Dernière mise à jour : 25-06-2018


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• Chemistry

 

Innovative Porous Materials for Glycomic Analysis in Hospitals

SL-DRF-18-0235

Research field : Chemistry
Location :

Service Nanosciences et Innovation pour les Materiaux, la Biomédecine et l'Energie

Laboratoire Edifices Nanométriques

Saclay

Contact :

Laurent MUGHERLI

Martine Mayne

Starting date : 01-10-2018

Contact :

Laurent MUGHERLI

CEA - DRF/IRAMIS/NIMBE/LEDNA

0169089427

Thesis supervisor :

Martine Mayne

CEA - DRF/IRAMIS/NIMBE/LEDNA

01 69 08 48 47

Personal web page : http://iramis.cea.fr/Phocea/Membres/Annuaire/index.php?uid=lmugherl

Laboratory link : http://iramis.cea.fr/nimbe/ledna/

More : http://joliot.cea.fr/drf/joliot/Pages/Entites_de_recherche/medicaments_technologies_sante/spi.aspx

Radiosensitive polymeric nano-objects

SL-DRF-18-0681

Research field : Chemistry
Location :

Service Nanosciences et Innovation pour les Materiaux, la Biomédecine et l'Energie

Laboratoire Innovation, Chimie des Surfaces Et Nanosciences

Saclay

Contact :

Geraldine CARROT

Jean-Philippe RENAULT

Starting date : 01-10-2017

Contact :

Geraldine CARROT

CEA - DRF/IRAMIS/NIMBE/LICSEN

01 69 08 21 49

Thesis supervisor :

Jean-Philippe RENAULT

CEA - DRF/IRAMIS/NIMBE/LIONS

01 69 08 15 50

This project involves the development of new delivery systems for drugs based on the degradation of polymers by irradiation. This new stimulus has never been explored for such applications. This permits to consider a coupled chemo- and radiotherapy beyond the simple trigger release. The objective is to perform the synthesis of a library of original amphiphilic copolymers, i.e. with a water-soluble/biocompatible part, together with a hydrophobic/radiosensitive part. The self-assembly into micelles or vesicles will lead to objects with a radiosensitive core where the drug will be located. The first advantage of these new systems is to control more finely the targeting of drug to the tumor cells and to avoid the side effects associated with chemotherapy and radiotherapy, by controlling the position of the irradiating beam and/or the absorbed doses.

Renewable boron and silicon based hydrides for C-O bond reduction in organic wastes

SL-DRF-18-0444

Research field : Chemistry
Location :

Service Nanosciences et Innovation pour les Materiaux, la Biomédecine et l'Energie

Laboratoire de Chimie Moléculaire et de Catalyse pour l'Energie

Saclay

Contact :

Thibault CANTAT

Starting date : 01-10-2018

Contact :

Thibault CANTAT

CEA - DRF/IRAMIS/NIMBE/LCMCE

01 69 08 43 38

Thesis supervisor :

Thibault CANTAT

CEA - DRF/IRAMIS/NIMBE/LCMCE

01 69 08 43 38

Personal web page : http://iramis.cea.fr/Pisp/thibault.cantat/index.html

Laboratory link : http://iramis.cea.fr/Pisp/thibault.cantat/index.html

The conversion of renewable organic feedstocks, including CO2 and biomass, requires the use of reactive, recyclable and, at the same time, energy efficient reductants. While H2 is commonly utilized in some reduction processes, its lack of reactivity, coupled to its mild redox potential, hampers its use in innovative reduction transformations. To circumvent these limitations, boron and silicon based hydrides are appealing, although their production is currently energy intensive and relies on the use of stoichiometric quantities of sodium metal. The doctoral project will tackle the drawbacks in hydrosilylation and hydroboration chemistry by unveiling the first electrocatalytic route to silicon and boron hydrides.

Bacteriostatic polymer films

SL-DRF-18-0680

Research field : Chemistry
Location :

Service Nanosciences et Innovation pour les Materiaux, la Biomédecine et l'Energie

Laboratoire Innovation, Chimie des Surfaces Et Nanosciences

Saclay

Contact :

Geraldine CARROT

Marie-Noelle BELLON-FONTAINE

Starting date : 01-10-2017

Contact :

Geraldine CARROT

CEA - DRF/IRAMIS/NIMBE/LICSEN

01 69 08 21 49

Thesis supervisor :

Marie-Noelle BELLON-FONTAINE

AgroParisTech - MICALIS/ INRA/ AgroParisTech

Personal web page : http://iramis.cea.fr/Phocea/Membres/Annuaire/index.php?uid=carrot

Laboratory link : http://iramis.cea.fr/nimbe/licsen/

Microbial multiplication is one of the most serious concerns for many commercial applications, particularly food packaging where the product deterioration is closely linked to both economic and environmental concerns (decrease of food waste by increasing the DLC, limit date of consumption). In this particular domain, the challenge is double: 1-to limit the growth of the total flora (to prevent the multiplication responsible for alteration), and 2-to preserve a certain amount of endogenous bacteria useful for an appropriate maturation of the fresh food product. The expected effect is therefore more bacteriostatic than fully antibacterial. We need materials that are both contact-active and biocide. In this context, stable cationic polymers are particularly interesting (low MCI in solution, Minimum Concentration for Inhibition) and the challenge here will be to develop a robust and efficient method to graft them onto various substrates such as glass, stainless steel and particularly polyolefins that are widely used in food packaging. This thesis project involves two academic Labs: CEA/NIMBE-LICSEN, expert in surface chemistry and AgroParisTech/INRA-MICALIS specialized in the study of bio-adhesion and biofilms. Industrial partners are also involved in this project.

Development of an integrated approach for characterization and quantification of protein surface coverage on antibody-functionalized particles:

SL-DRF-18-0862

Research field : Chemistry
Location :

Service Nanosciences et Innovation pour les Materiaux, la Biomédecine et l'Energie

Laboratoire Interdisciplinaire sur l'Organisation Nanométrique et Supramoléculaire

Saclay

Contact :

Jean-Philippe RENAULT

Serge PIN

Starting date :

Contact :

Jean-Philippe RENAULT

CEA - DRF/IRAMIS/NIMBE/LIONS

01 69 08 15 50

Thesis supervisor :

Serge PIN

CNRS - UMR 3299

01 69 08 15 49

Personal web page : http://iramis.cea.fr/Phocea/Membres/Annuaire/index.php?uid=jrenault

Laboratory link : http://iramis.cea.fr/nimbe/lions/

The goal of the proposed research therefore is to develop an integrated (i.e. physical and biochemical) approach for quantification of protein surface coverage on antibody-functionalized porous magnetic particles and systematic characterization of the antibodies’ functionality upon their grafting onto the porous structure. This integrated tool will serve to highlight the immunocapture potential of this novel microsphere technology platform compared to the conventional solid ones in diagnostic and biomedical applications.

 

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