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PhD subjects

14 sujets IRAMIS

Dernière mise à jour : 13-07-2020


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• Chemistry

 

SL-DRF-20-0492

Research field : Chemistry
Location :

Service Nanosciences et Innovation pour les Materiaux, la Biomédecine et l’Energie

Laboratoire de Chimie Moléculaire et de Catalyse pour l’Energie

Saclay

Contact :

Thibault CANTAT

Starting date :

Contact :

Thibault CANTAT
CEA - DRF/IRAMIS/NIMBE/LCMCE

01 69 08 43 38

Thesis supervisor :

Thibault CANTAT
CEA - DRF/IRAMIS/NIMBE/LCMCE

01 69 08 43 38

Personal web page : http://iramis.cea.fr/Pisp/thibault.cantat/index.html

Laboratory link : http://iramis.cea.fr/nimbe/lcmce/

Synthesis by laser pyrolysis of photocatalysts efficient for the obtention of alcene compounds

SL-DRF-20-0583

Research field : Chemistry
Location :

Service Nanosciences et Innovation pour les Materiaux, la Biomédecine et l’Energie

Laboratoire Edifices Nanométriques

Saclay

Contact :

Nathalie HERLIN

Starting date : 01-10-2020

Contact :

Nathalie HERLIN
CEA - DRF/IRAMIS/NIMBE/LEDNA

0169083684

Thesis supervisor :

Nathalie HERLIN
CEA - DRF/IRAMIS/NIMBE/LEDNA

0169083684

Personal web page : http://iramis.cea.fr/Phocea/Membres/Annuaire/index.php?uid=herlin

Laboratory link : http://iramis.cea.fr/nimbe/ledna/

Liquid-Liquid extraction in supercritical fluids and associated desextraction

SL-DRF-20-0558

Research field : Chemistry
Location :

Service Nanosciences et Innovation pour les Materiaux, la Biomédecine et l’Energie

Laboratoire Innovation, Chimie des Surfaces Et Nanosciences

Saclay

Contact :

Jean-Christophe GABRIEL

Starting date : 01-10-2020

Contact :

Jean-Christophe GABRIEL
CEA - DRF/IRAMIS/NIMBE/LICSEN

0676043559

Thesis supervisor :

Jean-Christophe GABRIEL
CEA - DRF/IRAMIS/NIMBE/LICSEN

0676043559

Personal web page : http://inac.cea.fr/Phocea/Pisp/index.php?nom=jean-christophe.gabriel

Laboratory link : http://iramis.cea.fr/nimbe/licsen/

More : https://fr.linkedin.com/in/jcpgabriel

The objective of this thesis work will be to demonstrate a viable liquid-liquid extraction approach in supercritical environment as well as for the desextraction. For that, the approach will have to make it possible to extract certain chemical elements, such as, for example, rare earth (for their own interest but also like simulant of actinides) in a specific manner from an aqueous solution. The latter will either be a simulation of a leachate or a solution resulting from a decontamination process.



During his thesis, the student will be exposed to a multidisciplinary environment and led to carry out experiments in various fields such as organic or molecular chemistry, physical chemistry, and characterization methods, publish results in international journals, even file patent application(s) if necessary as well as supervise undergraduate students. For the latter, it will have access to a very wide and varied range of equipments ranging from the optical microscope to the latest generation synchrotron (ESRF), X-ray diffraction, SAXS, as well as NMR, FTIR and UV spectroscopies.

This thesis is therefore an excellent opportunity for professional growth both from the point of view of your knowledge, your know-how or communication skills.

Selective reduction of nitrogen oxides (nitrates)

SL-DRF-20-0489

Research field : Chemistry
Location :

Service Nanosciences et Innovation pour les Materiaux, la Biomédecine et l’Energie

Laboratoire de Chimie Moléculaire et de Catalyse pour l’Energie

Saclay

Contact :

Lucile ANTHORE

Thibault CANTAT

Starting date :

Contact :

Lucile ANTHORE
CEA - DRF/IRAMIS/NIMBE/LCMCE

01 69 08 91 59

Thesis supervisor :

Thibault CANTAT
CEA - DRF/IRAMIS/NIMBE/LCMCE

01 69 08 43 38

Personal web page : http://iramis.cea.fr/nimbe/Phocea/Membres/Annuaire/index.php?uid=lanthore

Laboratory link : http://iramis.cea.fr/nimbe/lcmce/

Realization of efficient and innovative functionalization of graphene and carbon nanotubes for energy and material science

SL-DRF-20-0059

Research field : Chemistry
Location :

Service Nanosciences et Innovation pour les Materiaux, la Biomédecine et l’Energie

Laboratoire Innovation, Chimie des Surfaces Et Nanosciences

Saclay

Contact :

Stéphane CAMPIDELLI

Starting date : 01-10-2020

Contact :

Stéphane CAMPIDELLI
CEA - DRF/IRAMIS/NIMBE/LICSEN

01-69-08-51-34

Thesis supervisor :

Stéphane CAMPIDELLI
CEA - DRF/IRAMIS/NIMBE/LICSEN

01-69-08-51-34

Personal web page : http://iramis.cea.fr/Pisp/stephane.campidelli/

Laboratory link : http://iramis.cea.fr/nimbe/licsen/

The aim of this project is the development of new functional carbon nanotubes and graphene derivatives. So far, functionalization of carbon-based nano-objects is based either on the covalent grafting or on the non-covalent adsorption of molecules on the nanotube/graphene surfaces. It is well established that the covalent grafting of molecules give rise to robust conjugates since the nano-objects and the addends are linked through covalent bonds; however, the transformation of carbon atoms hybridized sp2 into sp3 in the nanotube framework induces a sizeable loss of their electronic properties. On the contrary, the non-covalent functionalization permits to better preserve the electronic properties of the nanotubes. So, for a number of applications, the non-covalent functionalization should be preferred. However, this approach suffers from a major drawback which is the lack of stability of the resulting assemblies. Indeed, molecules adsorbed onto the nanotube sidewall can desorb, more or less easily, when for example the solvent changes or the nanotubes are filtered and redispersed.

Recently we developed a method combining most advantages of these two techniques without their major drawbacks. From the applicative point of view, this method can be used to create new carbon-based nanomaterials for photovoltaic, catalytic and electronic applications.
Studies of recycling processes for printed circuit components

SL-DRF-20-1115

Research field : Chemistry
Location :

Service Nanosciences et Innovation pour les Materiaux, la Biomédecine et l’Energie

Laboratoire Innovation, Chimie des Surfaces Et Nanosciences

Saclay

Contact :

Jean-Christophe GABRIEL

Starting date : 01-09-2020

Contact :

Jean-Christophe GABRIEL
CEA - DRF/IRAMIS/NIMBE/LICSEN

0676043559

Thesis supervisor :

Jean-Christophe GABRIEL
CEA - DRF/IRAMIS/NIMBE/LICSEN

0676043559

Personal web page : https://www.researchgate.net/profile/Jean-Christophe_Gabriel

Laboratory link : http://iramis.cea.fr/nimbe/licsen/index.php

More : https://research.ntu.edu.sg/scarce

This thesis project is part of a joint thesis between the University of Paris-Saclay and the Nanyang Technological University (NTU) of Singapore. This project aims to develop new processes for extracting strategic materials (notably rare earths, refractory metals, precious metals) in a more environmentally friendly manner. It therefore falls within a framework of significant societal, economic and environmental impacts. More specifically, the subject aims to use advanced methods to allow the development of new commercially viable processes. This will include the rapid study of new processes for sorting components and liquid-liquid (L-L) or liquid-solid extraction using an integrated XRF, FTIR) functional microfluidic platform previously developed in the laboratory. This platform makes it possible to carry out the L-L extraction, and to measure online the solvent’s activity and ions concentrations in each of the two channels (aqueous and solvent), in a reproducible manner and in a controlled environment (https://theconversation.com/de-nouvelles-technologies-pour-recycler-les-dechets-electroniques-132530). The device can also be used for the study of phase diagrams of complex fluids. Upgrades of the existing platform will also be expected.



During his thesis, the student will be exposed to a multidisciplinary environment and led to carry out experiments in various fields such as inorganic chemistry, physico-chemistry, thermochemistry, micro-manufacturing in clean rooms (design and 3D printing) , instrumentation and nano-characterization methods. For the realization of the latter, he will have access to a very wide and varied range of equipment ranging from the optical microscope to the latest generation synchrotron (ESRF), including field or electronic effect microscopes, X-ray fluorescence, Fourier transform infrared spectroscopy, ICP etc.



This thesis is therefore an excellent opportunity for professional growth both from the point of view of your knowledge and your skills.
Functionnalized nanoparticles for radiosensitization

SL-DRF-20-0532

Research field : Chemistry
Location :

Service Nanosciences et Innovation pour les Materiaux, la Biomédecine et l’Energie

Laboratoire Innovation, Chimie des Surfaces Et Nanosciences

Saclay

Contact :

Geraldine CARROT

Jean-Philippe RENAULT

Starting date : 01-10-2017

Contact :

Geraldine CARROT
CEA - DRF/IRAMIS/NIMBE/LICSEN

01 69 08 41 47

Thesis supervisor :

Jean-Philippe RENAULT
CEA - DRF/IRAMIS/NIMBE/LIONS

01 69 08 15 50

Personal web page : http://iramis.cea.fr/Phocea/Membres/Annuaire/index.php?uid=carrot

Laboratory link : http://iramis.cea.fr/nimbe/licsen/

More : http://iramis.cea.fr/nimbe/lions/

This project involves the development of new delivery systems for drugs based on the degradation of polymers by irradiation. This new stimulus has never been explored for such applications. This permits to consider a coupled chemo- and radiotherapy beyond the simple trigger release. The objective is to perform the synthesis of a library of original amphiphilic copolymers, i.e. with a water-soluble/biocompatible part, together with a hydrophobic/radiosensitive part. The self-assembly into micelles or vesicles will lead to objects with a radiosensitive core where the drug will be located. The first advantage of these new systems is to control more finely the targeting of drug to the tumor cells and to avoid the side effects associated with chemotherapy and radiotherapy, by controlling the position of the irradiating beam and/or the absorbed doses.
Multi-purpose reaction-ready cubosomal platforms as new tools against antibiotic resistance

SL-DRF-20-0596

Research field : Chemistry
Location :

Service Nanosciences et Innovation pour les Materiaux, la Biomédecine et l’Energie

Laboratoire Interdisciplinaire sur l’Organisation Nanométrique et Supramoléculaire

Saclay

Contact :

Christophe FAJOLLES

Patrick GUENOUN

Starting date : 01-11-2019

Contact :

Christophe FAJOLLES
CEA - DSM/IRAMIS/NIMBE/LIONS

01 69 08 99 60

Thesis supervisor :

Patrick GUENOUN
CEA - DRF/IRAMIS/NIMBE/LIONS

01-69-08-74-33

Personal web page : http://iramis.cea.fr/Pisp/christophe.fajolles/

Laboratory link : http://iramis.cea.fr/nimbe/lions/

This PhD is part of a wider project bringing together scientists from Chemistry, Physical Chemistry and Biophysics to make and deliver a new lipid multifonctional nanoplatform (Reaction-ready cubosomes, RRC) for delivery purposes. In particular, the simultaneous delivery of two antibiotics (bitherapy) thanks to RRC is seeked for fighting against antibiotics resistance. The project proposes an innovative concept for the formation of a soft nano-structure, the reactive cubosome, whose dimensions and surface density will allow to finely control its final sophisticated properties.

In view recent results, we wish to develop a straightforward yet versatile pathway to prepare functional lipidic cubic-phases in-situ. The synthetic strategy will rely on the nucleophilic epoxide ring opening in water of commercially available oleoyl ester of glycidol (GMO) dispersed in MonoOlein (MO), the most frequently used lipid in the preparation of cubic phases.

The structure of cubosomes will be characterized by several techniques, such as small-angle X-ray scattering (SAXS), cryo-electron microscopy (cryo-EM), NMR and differential scanning calorimetry (DSC) and will guide the synthetic effort.
Synthesis and optical properties of graphene nanoparticles

SL-DRF-20-0058

Research field : Chemistry
Location :

Service Nanosciences et Innovation pour les Materiaux, la Biomédecine et l’Energie

Laboratoire Innovation, Chimie des Surfaces Et Nanosciences

Saclay

Contact :

Stéphane CAMPIDELLI

Starting date : 01-10-2020

Contact :

Stéphane CAMPIDELLI
CEA - DRF/IRAMIS/NIMBE/LICSEN

01-69-08-51-34

Thesis supervisor :

Stéphane CAMPIDELLI
CEA - DRF/IRAMIS/NIMBE/LICSEN

01-69-08-51-34

Personal web page : http://iramis.cea.fr/Pisp/stephane.campidelli/

Laboratory link : http://iramis.cea.fr/nimbe/licsen/

Graphene as a constituent of graphite was close to us for almost 500 years. However, it is only in 2005 that A. Geim and K. Novoselov (Nobel Prize in 2010) reported for the first time the obtaining of a nanostructure composed by a single layer of carbon atom. The exceptional electronic properties of graphene make it a very promising material for applications in electronic and renewable energies.



For many applications, one should be able to modify and control precisely the electronic properties of graphene. In this context, we propose to synthesize chemically graphene nanoparticles and study their absorption and photoluminescence properties. This project will be developed in collaboration with Physicists so the candidate will work in a multidisciplinary environment.
Utilization of gases from CO2 for the synthesis of high added value products

SL-DRF-20-0491

Research field : Chemistry
Location :

Service Nanosciences et Innovation pour les Materiaux, la Biomédecine et l’Energie

Laboratoire de Chimie Moléculaire et de Catalyse pour l’Energie

Saclay

Contact :

Emmanuel NICOLAS

Thibault CANTAT

Starting date : 01-10-2020

Contact :

Emmanuel NICOLAS
CEA - DRF/IRAMIS/NIMBE/LCMCE

01 69 08 26 38

Thesis supervisor :

Thibault CANTAT
CEA - DRF/IRAMIS/NIMBE/LCMCE

01 69 08 43 38

Personal web page : http://iramis.cea.fr/nimbe/Phocea/Membres/Annuaire/index.php?uid=enicolas

Laboratory link : http://iramis.cea.fr/nimbe/lcmce/

Bacteriostatic polymer films

SL-DRF-20-0531

Research field : Chemistry
Location :

Service Nanosciences et Innovation pour les Materiaux, la Biomédecine et l’Energie

Laboratoire Innovation, Chimie des Surfaces Et Nanosciences

Saclay

Contact :

Geraldine CARROT

Starting date : 01-10-2020

Contact :

Geraldine CARROT
CEA - DRF/IRAMIS/NIMBE/LICSEN

01 69 08 41 47

Thesis supervisor :

Geraldine CARROT
CEA - DRF/IRAMIS/NIMBE/LICSEN

01 69 08 41 47

Personal web page : http://iramis.cea.fr/Phocea/Membres/Annuaire/index.php?uid=carrot

Laboratory link : http://iramis.cea.fr/nimbe/licsen/

Microbial multiplication is one of the most serious concerns for many commercial applications, particularly food packaging where the product deterioration is closely linked to both economic and environmental concerns (decrease of food waste by increasing the DLC, limit date of consumption). In this particular domain, the challenge is double: 1-to limit the growth of the total flora (to prevent the multiplication responsible for alteration), and 2-to preserve a certain amount of endogenous bacteria useful for an appropriate maturation of the fresh food product. The expected effect is therefore more bacteriostatic than fully antibacterial. We need materials that are both contact-active and biocide. In this context, stable cationic polymers are particularly interesting (low MCI in solution, Minimum Concentration for Inhibition) and the challenge here will be to develop a robust and efficient method to graft them onto various substrates such as glass, stainless steel and particularly polyolefins that are widely used in food packaging. This thesis project involves two academic Labs: CEA/NIMBE-LICSEN, expert in surface chemistry and AgroParisTech/INRA-MICALIS specialized in the study of bio-adhesion and biofilms. Industrial partners are also involved in this project.
Bioactive polymer-grafted surfaces to limit the resistance of bacteria

SL-DRF-20-0793

Research field : Chemistry
Location :

Service Nanosciences et Innovation pour les Materiaux, la Biomédecine et l’Energie

Laboratoire Innovation, Chimie des Surfaces Et Nanosciences

Saclay

Contact :

Geraldine CARROT

Starting date : 01-10-2020

Contact :

Geraldine CARROT
CEA - DRF/IRAMIS/NIMBE/LICSEN

01 69 08 41 47

Thesis supervisor :

Geraldine CARROT
CEA - DRF/IRAMIS/NIMBE/LICSEN

01 69 08 41 47

Personal web page : http://iramis.cea.fr/nimbe/Phocea/Membres/Annuaire/index.php?uid=carrot

Laboratory link : http://iramis.cea.fr/nimbe/licsen/

Bacteria are always present in our environment whether natural, industrial, medical-hospital ... Their presence is generally not harmful and can even be beneficial. Nevertheless, some of them being pathogenic, they can represent a real danger and be at the origin of public health problems. Controlling this microbial flora and its development still remain a challenge in different areas of applications.



Very recent studies have shown that after only a few hours of adhesion to surfaces, bacteria were able to "feel" contact with the surface and to modify their proteome. Among the under or over expressed proteins, some are involved in the reactivity of bacteria to antimicrobials. These original data could explain some of the resistance phenomena observed today. What are the surfaces characteristics involved in these physiological evolutions? This is a crucial question to which it is now essential to provide elements of knowledge and answers, in order to help to the choice of surfaces and/or to the modifications of surfaces to be made (implants, medical environment, etc.).



The proposed thesis will therefore focus on the design of surfaces modified by polymers already studied previously (BRICAPAC project),1 showing a strong interaction with bacteria and a modular bacteriostatic effect. Here, we will try to better understand the impact of these interactions while changing the physicochemical parameters of the polymer layer. We will also graft other types of polymers with, for example, different charges, or to form amphiphilic or ampholytic copolymers. 3D surfaces will also be grafted (from nanoparticles) to study the impact of interactions in solution. Finally, nanostructured surfaces with defined patterns can be obtained from grafted polymers or nanoparticles, thanks to inkjet printing techniques. These new surfaces should make it possible to identify the factors behind the previously discussed adaptations (chemical composition, bacterial/surface adhesion interactions, mechanical stress, etc.). The proposed thesis will therefore concern the study of the reactivity of bacteria to antimicrobial agents, after adhesion to these surfaces. It will be carried out in close collaboration with a partner team specialized in bioadhesion and reactivity of immobilized bacteria (AgroParisTech INRA, UMR GMPA, Massy).

Composite materials based on TiO2 and graphene for energy application

SL-DRF-20-0593

Research field : Chemistry
Location :

Service Nanosciences et Innovation pour les Materiaux, la Biomédecine et l’Energie

Laboratoire Edifices Nanométriques

Saclay

Contact :

Nathalie HERLIN

Starting date : 01-10-2020

Contact :

Nathalie HERLIN
CEA - DRF/IRAMIS/NIMBE/LEDNA

0169083684

Thesis supervisor :

Nathalie HERLIN
CEA - DRF/IRAMIS/NIMBE/LEDNA

0169083684

Personal web page : http://iramis.cea.fr/Phocea/Membres/Annuaire/index.php?uid=herlin

Laboratory link : http://iramis.cea.fr/nimbe/ledna/

Reversible activation of strong bonds in wood lignin and CO2

SL-DRF-20-1203

Research field : Chemistry
Location :

Service Nanosciences et Innovation pour les Materiaux, la Biomédecine et l’Energie

Laboratoire de Chimie Moléculaire et de Catalyse pour l’Energie

Saclay

Contact :

Jean-Claude Berthet

Thibault CANTAT

Starting date : 01-10-2020

Contact :

Jean-Claude Berthet
CEA - DRF/IRAMIS/NIMBE/LCMCE

01 69 08 60 42

Thesis supervisor :

Thibault CANTAT
CEA - DRF/IRAMIS/NIMBE/LCMCE

01 69 08 43 38

Personal web page : http://iramis.cea.fr/Pisp/jean-claude.berthet/

Laboratory link : http://iramis.cea.fr/nimbe/LCMCE/

More : http://iramis.cea.fr/Pisp/thibault.cantat/publications.html

Wood lignins, like CO2, represent an attractive renewable carbon resource, which would make possible the replacement of petroleum resources to improve the environmental impact of the chemical industry. The transformation of theses molecules requires the activation of strong bonds, which can be carried out within a catalytic center, most often a metal ion. In this context, the formation of C-C bonds from CO2 as well as the transformation of Csp²-O bonds in lignin remain major challenges in catalysis. Our ability to develop catalytic systems capable of activating these bonds to promote their transformation within a catalytic cycle is greatly limited by the endothermic nature of the activation of strong bonds. To overcome this difficulty, the host laboratory proposes to develop a catalytic method of isotopic exchange, making it possible to detect the activation of strong C-C and C-O bonds.

 

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