Personal web page : http://iramis.cea.fr/Pisp/patrick.berthault/
Laboratory link : http://iramis.cea.fr/nimbe/lsdrm/
More : http://www.cortecnet.com
A large number of chemical processes are complex and require for their optimization to understand the reaction mechanisms by real-time observation of intermediate compounds and end products. Nuclear Magnetic Resonance (NMR) can perform this task, but this requires taking into account several aspects: to overcome the lack of intrinsic sensitivity of NMR, to bring the detection zone as close as possible to the synthesis reactor and to be able to accurately quantify the data obtained.
Recently LSDRM researchers developped and patented a 3D-printed NMR device based on a mini bubble pump associated with fluidics and micro-detection, installable on a commercial probe inside the NMR magnet. An insert version plugged into a micro-imaging probe and a version using an inductive coupling between the micro-coil and the commercial coil have been developed. The system allows a significant improvement of the NMR signal for the slowly relaxing nuclei, since the constituents of the reaction mixture are located in a magnetic field close to that of the NMR study, thus allowing a pre-polarization of the whole solution. Moreover, thanks to the controlled of the flow, between two scans, the fresh spins replace those previously excited in the detection region; it is therefore not necessary to wait several relaxation times between each scan acquisition.
Based on CortecNet's expertise in the synthesis of stable isotope-enriched compounds, and LSDRM, a research laboratory recognized for its know-how in the creation of innovative devices for improving the NMR technique, the objective of this research project is to develop a complete NMR monitoring system, in situ, of chemical syntheses in order to provide organic chemists with an indispensable measuring instrument in their daily activities.