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2 sujets IRAMIS/CIMAP

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2D materials under irradiation for tomorrow's functionalities

SL-DRF-24-0400

Research field : Radiation-matter interactions
Location :

Centre de recherche sur les Ions, les Matériaux et la Photonique (CIMAP)

Centre de recherche sur les Ions, les Matériaux et la Photonique (CIMAP)

Saclay

Contact :

Stéphane GUILLOUS

Clara GRYGIEL

Starting date : 01-10-2024

Contact :

Stéphane GUILLOUS
CEA - DRF/IRAMIS/CIMAP/CIMAP

02.31.45.48.88

Thesis supervisor :

Clara GRYGIEL
CEA - DSM/IRAMIS/CIMAP

+33 2 31 45 49 34

Personal web page : https://cv.archives-ouvertes.fr/grygiel-clara

Laboratory link : http://cimap.ensicaen.fr/

In view of the challenges posed by global warming, some fundamental research is focusing on optimizing the properties of materials for gas capture (e.g. CO2), filtration, desalination or the conversion of water to H2 by photocatalysis. Two-dimensional materials (graphene, MoS2, hBN, etc.) nanostructured by ion irradiation have recently shown unique and original properties to improve the efficiency of these processes. The introduction of surface modifications to these materials can be used to tailor their properties to specific requirements. Irradiation by fast heavy ions, such as those produced on the GANIL facility, or by low-energy ions produced on CIMAP's PELIICAEN device, induces surface modifications on the nanometric scale.

In this thesis, we propose to gain a better understanding of the processes involved in ion-beam structuration and the modification of 2D material properties as a function of the influence of different irradiation parameters on the local radiation-induced modifications.
Impact of LET on biological response to Flash irradiations

SL-DRF-24-0262

Research field : Radiobiology
Location :

Centre de recherche sur les Ions, les Matériaux et la Photonique (CIMAP)

Centre de recherche sur les Ions, les Matériaux et la Photonique (CIMAP)

Saclay

Contact :

François CHEVALIER

Gérard BALDACCHINO

Starting date : 01-10-2024

Contact :

François CHEVALIER
CEA - DRF/IRAMIS/CIMAP

02 31 45 45 64

Thesis supervisor :

Gérard BALDACCHINO
CEA - DRF/IRAMIS/LIDYL

01 69 08 57 02

Personal web page : https://cimap.ensicaen.fr/spip.php?article206

Laboratory link : https://cimap.ensicaen.fr/spip.php?rubrique113

Recent studies with electron and proton beams have shown that irradiation at dose rates above 40 Gy/s can be as effective in inhibiting tumor growth as irradiation at the conventional dose currently used (typically 1 Gy/min) but much less toxic to healthy tissues. This phenomenon is known as the “FLASH effect”. This effect is considered one of the most important discoveries in the recent history of radiobiology due to its potential to improve the therapeutic window between tumor control and normal tissue toxicity. Recent studies show that the biological mechanisms of the FLASH effect are linked to differential tissue oxygenation. However, the exact mechanisms of the cellular biological effects of FLASH irradiations are not completely clear and some are even contradictory.

The objective of this project is a molecular characterization of the FLASH effect on a model system perfectly controlled in vitro. FLASH irradiations of cancer cells and healthy cells will be compared to conventional dose rate irradiations using electrons and carbon ions in the two associated laboratories. The differential effect will be related to the oxygenation condition of the cells, REDOX/mitochondrial metabolism and general changes in cellular metabolism.

 

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